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Acute pulmonary embolism (PE) can be potentially fatal if not diagnosed and treated early. Mortality in untreated cases can be as high as 30%. Atypical presentation and submassive PE can be missed due to subtle clinical features. Computerized tomography pulmonary angiogram is expensive, exposes to radiation and carries the risk of contrast nephropathy or anaphylactic reactions. On the contrary, McConnell's sign, which is a highly specific sign of PE, can be demonstrated at the bedside with a transthoracic echocardiogram (TTE). Here we discuss two cases where bedside TTE demonstrating McConnell's sign helped in the diagnosis and treatment of PE.
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http://dx.doi.org/10.7759/cureus.6240 | DOI Listing |
J Pak Med Assoc
August 2025
National Institute of Cardiovascular Diseases, Karachi, Pakistan.
Although post-operative acute pulmonary embolism (PE) is relatively rare, it poses a substantial risk of morbidity and mortality. We report the case of a 45-year-old hypertensive woman who presented with acute chest pain and dyspnoea eight days following a hysterectomy. On admission, she was tachycardic, hypotensive, and hypoxic.
View Article and Find Full Text PDFJACC Case Rep
July 2025
Department of Internal Medicine, Lankenau Medical Center, Wynnewood, Pennsylvania, USA.
Background: Kratom (Mitragyna speciosa) is a psychoactive herbal supplement with stimulant and opioid-like properties, with emerging reports linking it to cardiovascular toxicity. However, its association with right ventricular (RV) function remains unclear.
Case Summary: We report the case of a 52-year-old man who presented in shock with hypoxia and multiorgan dysfunction.
Radiol Case Rep
August 2025
Faculty of Medicine and Pharmacy, Mohammed Ist University, Oujda, Morocco.
Thromboembolic disease encompasses a wide range of disorders that include deep vein thrombosis and pulmonary embolism, within its clinical spectrum. The occurrence of pulmonary embolism in pregnant woman is a major cause of maternal mortality and presents significant management challenges, particularly when associated with thrombophilia. A condition characterized by an increased predisposition to thrombosis due to genetic defects.
View Article and Find Full Text PDFBackground: Right heart (RH) strain in the setting of pulmonary embolisms can significantly increase the risk of mortality. Thus, screening for risk of complications in these patients is crucial. The goal of our study was to assess the strength of specific diagnostic findings of RH strain for predicting adverse outcomes including mortality, hospital length of stay, and the requirement of advanced interventions.
View Article and Find Full Text PDFStat Med
March 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA.
As individuals are exposed to a myriad of potentially harmful pollutants every day, it is important to determine which actors have the greatest influence on health outcomes. However, jointly modeling the associations of multiple pollutant exposures is often hindered by the presence of highly correlated chemicals originating from a common source. A popular approach to analyzing associations between a disease outcome and several highly correlated exposures is Weighted Quantile Sum Regression (WQSR) modeling.
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