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This paper presents a method that can be applied to weak feedback and full-range moderate feedback in the field of self-mixing interference measurement, and the target motion displacement can be obtained by multiple Hilbert transforms of the signal after the secondary envelope extraction. Simulations and experiments of multiple micro-vibration measurements were performed with different optical feedback factors, and the results were consistent with theoretical analysis. This method effectively eliminates the impact of the self-mixing interference signal with fringe shift on micro-vibration reconstruction.
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http://dx.doi.org/10.1364/AO.58.009392 | DOI Listing |
Bioorg Chem
September 2025
School of Cosmetic Science, Mae Fah Luang University, Chiang Rai 57100, Thailand. Electronic address:
Although antimicrobial peptides possess potent antimicrobial activities, the high cost of production, based on amino acid length, has limited their therapeutic and cosmeceutical applications. This study aimed to produce and characterize de novo designed antimicrobial peptides derived from WSKK11 and WSRR11 for efficacy against acne-causing bacteria. Ten designed peptides were evaluated for antimicrobial, hemolytic, and cytotoxic activities, as well as, secondary structures by FTIR and modes of action.
View Article and Find Full Text PDFFront Public Health
September 2025
Department of Hospital Information Network, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Background: Over the past decade, traditional Chinese medicine (TCM) hospitals in China have experienced significant growth. However, their developmental status remains unclear, posing challenges to the formulation and optimization of relevant healthcare policies. This study aimed to assess the operational efficiency of TCM hospitals in Shaanxi Province and explore its influencing factors, thereby providing empirical evidence to support performance improvement.
View Article and Find Full Text PDFLancet Oncol
September 2025
British Columbia Cancer Agency, Vancouver, BC, Canada.
Background: The role of metastasis-directed therapy (MDT) in castration-resistant prostate cancer (CRPC) remains unclear. Prostate Cancer Study 9 (PCS-9) aimed to evaluate the benefits of stereotactic body radiotherapy (SBRT) in addition to standard systemic therapy in patients with oligometastatic CRPC.
Methods: This open-label, randomised, phase 2 trial was conducted across 13 Canadian academic and community oncology centres.
Nat Commun
September 2025
Centre for the AIDS Programme of Research in South Africa (CAPRISA), Durban, South Africa.
Broadly neutralizing antibodies (bNAbs) offer a promising strategy for HIV prevention. Subcutaneous (SC) administration is more feasible than intravenous delivery but may be limited by prolonged administration times and multiple injections. Here we report a pharmacokinetic (PK) modelling study, an unspecified exploratory analysis that involved 57 HIV-negative African women (median age 25 years; BMI range 18.
View Article and Find Full Text PDFUltrastruct Pathol
September 2025
Department of Microbiology and Immunology, Northeast Ohio Medical University, Rootstown, OH, USA.
Efficient transcriptional activation and replication of the human immunodeficiency virus (HIV-1) is dependent on Tat protein. Initial observations have shown that human leukemia T lymphocytes (Jurkat cells aka Wild type or WT) transfected with plasmid as Control (CTJ) cells, and CTJ transfected by electroporation with (TJ cells) showed growth and maintenance resulting in giant and small cells with accumulated corpses. The lack of fine structure in Jurkat cells and both transfected cells aimed at us to verify their respective ultrastructure modifications.
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