Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
CXCL8 (also known as IL-8) can produce different biological effects by binding to its receptors: CXCR1, CXCR2, and the Duffy antigen receptor for chemokines (DARC). CXCL8 and its receptors are associated with the development of various tumor types, especially colorectal cancer and its liver metastases. In addition to promoting angiogenesis, proliferation, invasion, migration, and the survival of colorectal cancer (CRC) cells, CXCL8 and its receptors have also been known to induce the epithelial-mesenchymal transition (EMT) of CRC cells, to help them to escape host immunosurveillance as well as to enhance resistance to anoikis, which promotes the formation of circulating tumor cells (CTCs) and their colonization of distant organs. In this paper, we will review the established roles of CXCL8 signaling in CRC and discuss the possible strategies of targeting CXCL8 signaling for overcoming CRC drug resistance and cancer progression, including direct targeting of CXCL8/CXCR1/2 or indirect targeting through the inhibition of CXCL8-CXCR1/2 signaling.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6886345 | PMC |
| http://dx.doi.org/10.1155/2019/8023460 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Expression of hormonal receptors and Toll-like receptors in cultured canine uterine explants with pseudoplacentational endometrial hyperplasia and bacterial-elicited endometrial inflammation.
PLoS One
September 2025
Departamento de Clínica e Cirurgia Veterinária, Escola de Veterinária, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Pseudoplacentational endometrial hyperplasia (PEH) is a common uterine lesion in dogs. A high frequency of pyometra has been associated with PEH in dogs, suggesting that PEH might be related to the pathogenesis of pyometra. This study aimed to assess transcription levels and expression of Toll like receptors (TLR) 1, 2 and 4; alpha estrogen receptors (ESR1), progesterone receptors (PR) and prolactin receptors (PRLR) in uteri with PEH.
View Article and Find Full Text PDFInduction of CXCL8 by endoplasmic reticulum stress promotes migration and invasion of esophageal squamous cell carcinoma through activation of SMAD2/3.
Mol Med Rep
November 2025
Laboratory of Pathology, Hebei Cancer Institute, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China.
Endoplasmic reticulum stress (ERS) is a protective stress response aimed at mitigating its own abnormal proteins, which is closely associated with tumors. However, the molecular mechanism of ERS in the pathogenesis of esophageal squamous cell carcinoma (ESCC) remains unclear. In the present study, RNA sequencing was carried out in the ESCC ERS cell model , and differentially expressed genes were screened, among which CXCL8 with exhibited differential expression which was studied.
View Article and Find Full Text PDFTLR2 and IRF8 are the biomarkers associated with hypoxia in steroid-induced osteonecrosis of the femoral head via bioinformatics analysis and experimental validation.
BMC Musculoskelet Disord
September 2025
Department of Orthopedics, Linyi People's Hospital, Linyi, 276000, Shandong, China.
Background: Accumulating evidence has shown that hypoxia harbors a dominant role in pathophysiological mechanisms of steroid-induced osteonecrosis of the femoral head (SONFH), but the significance of hypoxia in SONFH is still rarely explored.
Methods: By integrating SONFH gene expression matrix GSE123568 and hypoxia gene sets, the hypoxia-related differentially expressed genes (DEGs) were screened out. Functional and gene set enrichment analyses were conducted to reveal the underlying mechanisms of hypoxia-related DEGs.
Profiling Cytokines According to the Presence or Absence of Small-for-Gestational Age Using Amniotic Fluid Retrieved During Cesarean Section From Pregnant Women With Early-Onset Preeclampsia.
J Korean Med Sci
September 2025
Department of Pediatrics, Keimyung University Dongsan Hospital, Daegu, Korea.
Background: Preeclampsia (PE) is a hypertensive disorder and a major cause of maternal and fetal mortality. We aimed to investigate the molecular properties of early-onset PE, which requires delivery before 34 weeks' gestation by analyzing the molecular cytokine profile of amniotic fluid obtained during cesarean section from pregnant women with early-onset PE, based on the presence or absence of small-for-gestational age (SGA).
Methods: This study included 73 pregnant women with early-onset PE among which 21 women had SGA infants, whose birth weight was less than the 10th percentile of the gestational age-specific birth weight.
Neutrophil expression of CD41/CD61 complex contributes to their adhesiveness in both healthy individuals and heart failure patients.
BMC Immunol
August 2025
Research center, Montreal Heart Institute, 5000 Belanger Street, Montreal, Qc, H1T 1C8, Canada.
Background: Neutrophils can release pro-inflammatory cytokines and neutrophil extracellular traps (NETs), leading to vascular thrombosis. Neutrophil-platelet interaction, a major component of thrombosis, is more pronounced in inflammatory pathologies, such as heart failure (HF). Recently, the platelet receptor CD41/CD61 (GPIIb/IIIa), known for its role in platelet adhesion and aggregation via its binding to fibrinogen, was found on the membrane of neutrophils from lung cancer patients.
View Article and Find Full Text PDF