Article Synopsis
- The study re-evaluates hypotheses about the origins of eukaryotic cells in relation to the universal 'tree of life' and highlights that the tree's structure can vary based on included taxa and genomic data.
- The authors reanalyzed evidence by applying supertree and coalescent methods on over 3,000 gene families of archaea and eukaryotes.
- Their findings indicate that eukaryotes are derived from archaea, specifically showing a close relationship with Asgard archaea and suggesting Heimdallarchaeota as the closest relatives to eukaryotic nuclei.
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Article Abstract
Hypotheses about the origin of eukaryotic cells are classically framed within the context of a universal 'tree of life' based on conserved core genes. Vigorous ongoing debate about eukaryote origins is based on assertions that the topology of the tree of life depends on the taxa included and the choice and quality of genomic data analysed. Here we have reanalysed the evidence underpinning those claims and apply more data to the question by using supertree and coalescent methods to interrogate >3,000 gene families in archaea and eukaryotes. We find that eukaryotes consistently originate from within the archaea in a two-domains tree when due consideration is given to the fit between model and data. Our analyses support a close relationship between eukaryotes and Asgard archaea and identify the Heimdallarchaeota as the current best candidate for the closest archaeal relatives of the eukaryotic nuclear lineage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6942926 | PMC |
| http://dx.doi.org/10.1038/s41559-019-1040-x | DOI Listing |
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