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The behavior of phyllodes tumors is unpredictable and can behave as benign fibroadenomas or malignant neoplasms mimicking the course of aggressive sarcomas, characterized by distant metastases and a high short-term mortality. The malignant forms are treated with surgery and adjuvant chemotherapy, but often with poor outcomes. We examine the first reported case of an aggressive osteosarcoma subtype of phyllodes tumor that recurred in the skull after total mastectomy and adjuvant chemotherapy. The skull lesion was treated with excision, and the patient currently remains disease-free.
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http://dx.doi.org/10.1177/2036361319890710 | DOI Listing |
Pediatr Dev Pathol
September 2025
Histopathology Section, Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.
Introduction: Phyllodes tumor (PT) are rarely seen in young population. Some authors believe that PT behave less aggressively in young patients and the need for aggressive management is questioned.
Objective: We aimed to describe the clinicopathological features of PT in pediatric and adolescent population.
Malignant phyllodes tumors of the breast are rare fibroepithelial neoplasms with aggressive behavior and high recurrence rates. They pose significant diagnostic and therapeutic challenges due to their overlap with other malignancies, necessitating accurate diagnosis and a tailored treatment approach to improve patient outcomes. A 29-year-old Asian female initially underwent a lumpectomy for a right breast mass diagnosed as a phyllodes tumor on histopathology.
View Article and Find Full Text PDFWorld J Clin Pediatr
September 2025
Pathology and Laboratory Medicine, Women and Infants Hospital, Warren Alpert Medical School of Brown University, Providence, RI 02905, United States.
Background: Fibroadenomas (FA) and phyllodes tumors (PT) are fibroepithelial neoplasms and are difficult to differentiate radiographically and histologically. We present a partially infarcted borderline PT in an adolescent with rapid tumor enlargement within 24 hours. Tumor infarction made the diagnostic work-up difficult.
View Article and Find Full Text PDFJ Imaging
August 2025
Department of Electrical and Computer Engineering, California State University, Fullerton, CA 92831, USA.
Breast cancer is a significant cause of cancer-related mortality among women around the globe, underscoring the need for early and accurate diagnosis. Typically, histopathological analysis of biopsy slides is utilized for tumor classification. However, it is labor-intensive, subjective, and often affected by inter-observer variability.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Emergency Surgery, The First Hospital of Jilin University, Changchun, China.
Background And Objectives: Breast carcinosarcoma is rare. This article reports a case of diagnosis and treatment to enhance clinicians' understanding and experience in managing this disease.
Methods: A 44-year-old patient with breast carcinosarcoma treated at the Breast Surgery Department of the First Hospital of Jilin University is reported, highlighting the challenges in the diagnostic process.