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We present a case of a 54-year-old man with primary angiitis of the central nervous system (PACNS) who was initially admitted to a psychiatric clinic with a diagnosis of delirium. We discuss the difficulty in establishing the diagnosis of PACNS and provide the reader with some recommendations on how to promptly and correctly diagnose this disease in order to avoid potentially lethal outcomes.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875412 | PMC |
http://dx.doi.org/10.1155/2019/8074258 | DOI Listing |
Front Immunol
September 2025
Department of Rheumatology and Immunology, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Background: The coexistence of neuropsychiatric systemic lupus erythematosus (NPSLE) and primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS) (PCNS DLBCL) is extremely rare in clinical practice. This article retrospectively analyzes the clinical manifestations, imaging examinations, pathological diagnosis, and treatment process of a patient with NPSLE, from the appearance of intracranial abnormal signal shadows to the final diagnosis of PCNS DLBCL.
Case Summary: A 32-year-old Chinese female patient had previously visited our hospital due to vomiting and delirium and was diagnosed with NPSLE.
Stroke
September 2025
Division of Neurointerventional Surgery, Department of Neurosurgery, University of Maryland Medical Center, Baltimore (H.C., D.G.).
Background: Retinal artery occlusion (RAO) is a form of ischemic stroke per the American Heart Association, yet high-level evidence guiding management and prognostication is limited. The risk of future cerebral infarction following nonarteritic isolated RAO (iRAO; without concomitant cerebral infarction) is unclear. This study compares the risk of stroke recurrence following iRAO versus nondisabling ischemic cerebrovascular events (NICEs), including transient ischemic attacks and minor ischemic strokes.
View Article and Find Full Text PDFZh Nevrol Psikhiatr Im S S Korsakova
September 2025
Prof. V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russia.
Non-traumatic intracerebral hemorrhages of multiple localization are most often associated with coagulopathies, uncontrolled use of anticoagulants, vasculitis, thrombosis of venous sinuses, amyloid angiopathy, and other conditions. If secondary risk factors cannot be identified, such hemorrhages are regarded as primary multiple due to hypertension. Their pathogenesis is poorly studied, with most researchers suggesting a sequential rupture of blood vessels when the first hemorrhage contributes to developing another one through increasing intracranial and blood pressure.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine, Shenzhen, Guangdong Province, China.
This study aims to identify the primary active components of Danshen (Salvia miltiorrhiza) and explore the potential mechanisms underlying its therapeutic effect on Kawasaki disease (KD). Active components of Danshen and their action targets were screened using traditional Chinese medicine systems pharmacology and SwissTargetPrediction databases. KD-related targets were retrieved from Online Mendelian Inheritance in Man, Pharmacogenomics Knowledge Base, and GeneCards databases.
View Article and Find Full Text PDFCureus
July 2025
Department of Neurology, Mayo Clinic, Phoenix, USA.
Cerebral amyloid angiopathy (CAA) is associated with amyloid-beta deposition in cerebrovascular vessels, leading to spontaneous intracerebral hemorrhage (ICH). A rare manifestation, amyloid beta-related angiitis (ABRA), presents with symptoms including subacute progressive headaches, cognitive decline, and focal neurological deficits. This case report discusses a 78-year-old female patient with a history of hypertension who exhibited symptoms consistent with ABRA, including headaches and memory impairments.
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