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Introduction: Brazil experiences a large number of visceral leishmaniasis (VL) cases. Our objective was to examine both spatial patterns of dispersion and space-time trends for this disease.
Methods: We used all autochthonous confirmed cases of VL in Brazil from 2001 to 2017.
Results: Throughout Brazil, 53,715 human cases of VL were recorded. The Northeast, Southeast, and Midwest regions of Brazil were the most affected areas and presented a higher risk of transmission. Regarding spatiotemporal variation, significant differences were observed each year, with a peak in 2005.
Conclusions: The dynamics of VL showed a clear non-random pattern of spread in Brazil.
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http://dx.doi.org/10.1590/0037-8682-0240-2019 | DOI Listing |
J Hum Evol
September 2025
Sustainability Solutions Research Lab, University of Pannonia, Egyetem utca 10, H-8200, Veszprém, Hungary. Electronic address:
Denisovans contributed notably to the genomes of present-day East and Southeast Asians. However, the relationship between the inhabited paleohabitats and the adaptive genetic traits related to infections in modern humans remains underexplored. This study uses geospatial techniques to analyze climatic factors associated with three Denisovan archaeological sites linked to nine specimens.
View Article and Find Full Text PDFTurkiye Parazitol Derg
September 2025
Ege University Faculty of Medicine, Department of Parasitology, İzmir, Türkiye.
Objective: Leishmaniasis, caused by protozoan parasites of the spp., presents significant global health challenges, with visceral leishmaniasis (VL) and cutaneous leishmaniasis forms causing severe morbidity and mortality. Macrophages serve as primary host cells, where spp.
View Article and Find Full Text PDFTravel Med Infect Dis
September 2025
Hospital for Tropical Diseases, University College London Hospitals NHS Foundation Trust. London, UK; Clinical Research Department, London School of Hygiene and Tropical Medicine, London, UK.
Introduction: Leishmaniasis is a parasitic disease caused by protozoa of the genus Leishmania. Disease phenotypes are heterogenous, and diagnosis is frequently delayed. Treatment is often challenging, and international guidelines recommend consultation with experts.
View Article and Find Full Text PDFChem Biol Drug Des
September 2025
Laboratory of Biochemistry and Animal Toxins, Institute of Biotechnology, Federal University of Uberlandia, Uberlandia, MG, Brazil.
Leishmaniasis, a disease caused by Leishmania parasites, poses a significant health threat globally, particularly in Latin America and Brazil. Leishmania amazonensis is an important species because it is associated with both cutaneous leishmaniasis and an atypical visceral form. Current treatments are hindered by toxicity, resistance, and high cost, driving the need for new therapeutic targets and drugs.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Institute of Immunology & Infection Research, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom.
Background: Neglected tropical diseases (NTDs) are a group of 21 diseases affecting approximately 1.5 billion people globally. Significant progress has been made in their control: by March 2024, 50 countries had eliminated at least one NTD, with 13 of these countries eliminating at least two.
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