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http://dx.doi.org/10.1136/annrheumdis-2019-216504 | DOI Listing |
Arch Pharm Res
September 2025
Department of Biosciences, JIS University, 81, Nilgunj Road, Agarpara, Kolkata, West Bengal, 700109, India.
Bacoside A (BCA), a triterpenoid saponin isolated from Bacopa monnieri, exhibits diverse pharmacological properties, including neuroprotective, hepatoprotective, anti-stress, anti-inflammatory, and anti-ulcer effects. In the present study, BCA demonstrates pronounced anticancer activity against K562 chronic myelogenous leukemia (CML) cells by modulating autophagy-apoptosis dynamics. BCA induces dose- and time-dependent cytotoxicity in K562 cells while sparing normal human peripheral blood mononuclear cells (hPBMCs) and Vero cells, indicating therapeutic selectivity.
View Article and Find Full Text PDFIntroduction: Endothelial dysfunction has been reported in rheumatoid arthritis (RA) patients without classical cardiovascular risk factors, but findings remain inconsistent.
Objectives: To assess whether endothelial function is impaired in RA with moderate inflammatory burden in the absence of established cardiovascular risk factors.
Patients And Methods: This cross-sectional study was conducted in 64 patients with RA without classical CV risk factors and 60 healthy age- and sex-matched controls.
Tidsskr Nor Laegeforen
September 2025
Nevrologisk avdeling, Haukeland universitetssjukehus, og, Klinisk institutt 1, Universitetet i Bergen.
Immune-mediated toxicity from the use of immune checkpoint inhibitors is very common and can affect both the peripheral and central nervous systems. Given the potentially serious side effects, clinicians must maintain a high level of vigilance. The aim of this clinical review is to describe neurotoxic complications associated with the use of immune checkpoint inhibitors in cancer treatment.
View Article and Find Full Text PDFJ Exp Biol
September 2025
Department of Biology, University of Washington, Seattle, Washington, USA.
Feeding on the nutrients from fruits and flowers is vital for mosquitoes and increases their lifespan, reproduction, and flight activity. Olfaction is a key sensory modality in mediating mosquito responses to nutrient sources. Previous studies have demonstrated that fruits and flowers can vary in attractiveness to mosquitoes, with some sources preferred over others.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Department of General Surgery, Faculty of Medicine, Atatürk University, Erzurum, Türkiye.
Rejection following liver and kidney transplantation remains a major barrier to long-term graft survival. Early and reliable detection of rejection is crucial for optimizing patient outcomes and guiding personalized therapeutic approaches. Despite ongoing efforts, currently available serum-based biomarkers often fail to provide sufficient sensitivity and specificity for early diagnosis.
View Article and Find Full Text PDF