Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
No effective treatment is yet available to reduce infarct size and improve clinical outcomes after acute myocardial infarction by enhancing early reperfusion therapy using primary percutaneous coronary intervention. The study showed that Kyoto University Substance 121 (KUS121) reduced endoplasmic reticulum stress, maintained adenosine triphosphate levels, and ameliorated the infarct size in a murine cardiac ischemia and reperfusion injury model. The study confirmed the cardioprotective effect of KUS121 in a porcine ischemia and reperfusion injury model. These findings confirmed that KUS121 is a promising novel therapeutic agent for myocardial infarction in conjunction with primary percutaneous coronary intervention.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6834964 | PMC |
| http://dx.doi.org/10.1016/j.jacbts.2019.06.001 | DOI Listing |
Publication Analysis
Top Keywords
myocardial infarction
12
infarct size
8
primary percutaneous
8
percutaneous coronary
8
coronary intervention
8
ischemia reperfusion
8
reperfusion injury
8
injury model
8
cardioprotective effects
4
effects vcp modulator
4