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http://dx.doi.org/10.1136/jnnp-2019-321694 | DOI Listing |
Animals (Basel)
July 2025
Facultad de Agronomía, Universidad de la República, Av. Garzón 780, Montevideo 12900, Uruguay.
Phytochemicals are a potential alternative to antibiotic growth promoters. This study evaluated the effects of phytochemicals (curcuminoids, trans-cinnamaldehyde, and piperine) and monensin on performance and ruminal fermentation during the transition period in grazing dairy cows. In a complete randomized design, 60 Holstein cows (36 multiparous, 24 primiparous; 9 fistulated) were assigned to (1) control (CTL), (2) monensin (MON, 0.
View Article and Find Full Text PDFUnited European Gastroenterol J
July 2025
Sheba Medical Center, Tel-Hashomer, Affiliated With the Tel Aviv University, Tel Aviv, Israel.
Background: Metabolites are key mediators of various physiological functions. However, there is a lack of data linking their levels to future Crohn's Disease (CD) flares.
Objective: We aimed to identify systemic and gut metabolic changes that precede flare and generate metabolite-based indexes that predict flare using a test cohort, with validation using an independent cohort.
Epilepsia
June 2025
Department of Radiology, Second Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
Objective: Ketogenic diet therapy (KDT) is a safe and effective intervention for drug-resistant epilepsy (DRE), yet its neural mechanisms remain unclear. This study aimed to explore how KDT-induced changes in brain network dynamics relate to its therapeutic efficacy.
Methods: Resting-state functional magnetic resonance imaging was performed on 38 DRE patients at both pre- and post-KDT stages, alongside 35 healthy controls.
Metabolites
April 2025
Sports Nutrition Center, National Institute of Sports Medicine, Beijing 100029, China.
Prolonged microgravity environments impair skeletal muscle homeostasis by triggering fiber-type transitions and metabolic dysregulation. Although exercise and nutritional interventions may alleviate disuse atrophy, their synergistic effects under microgravity conditions remain poorly characterized. This study investigated the effects of an 8-week ketogenic diet combined with aerobic exercise in hindlimb-unloaded mice on muscle fiber remodeling and metabolic adaptation.
View Article and Find Full Text PDFFront Nutr
March 2025
Department of Clinical Science, University of Bergen, Bergen, Norway.
Background: Evidence for the clinical utility of ketogenic diets (KD) is mounting. The transition to a KD (keto-induction) can however trigger unpleasant transient symptoms (≪keto-flu≫) which may deter continued adherence. Knowledge of strategies that mitigate symptoms during keto-induction may facilitate adoption of a KD.
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