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Here, we report on a new record in the acquisition time for fast neutron tomography. With an optimized imaging setup, it was possible to acquire single radiographic projection images with 10 ms and full tomographies with 155 projections images and a physical spatial resolution of 200 µm within 1.5 s. This is about 6.7 times faster than the current record. We used the technique to investigate the water infiltration in the soil with a living lupine root system. The fast imaging setup will be part of the future NeXT instrument at ILL in Grenoble with a great field of possible future applications.
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http://dx.doi.org/10.1364/OE.27.028640 | DOI Listing |
Mol Cell Proteomics
September 2025
Institute of Biotechnology, HiLIFE, Faculty of Medicine, University of Helsinki, Helsinki, Finland. Electronic address:
Structural proteomics has undergone a profound transformation, driven by the convergence of advanced experimental methodologies and computational innovations. Cutting-edge mass spectrometry (MS)-based approaches, including cross-linking MS (XL-MS), hydrogen-deuterium exchange MS (HDX-MS), and limited proteolysis MS (LiP-MS), now enable unprecedented insights into protein topology, conformational dynamics, and protein-protein interactions. These methods, complemented by affinity purification (AP), co-immunoprecipitation (co-IP), proximity labeling (PL), and spatial proteomics techniques, have expanded our ability to characterize the structural proteome at a systems-wide scale.
View Article and Find Full Text PDFSci Rep
August 2025
Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, People's Republic of China.
In modern Boron neutron capture therapy (BNCT) treatment planning, F-BPA (F-boronophenylalanine) PET (positron emission tomography) imaging is used to assess boron uptake and guide accurate dose delivery. This study evaluates the geometric and dosimetric differences between target volumes defined by MRI (magnetic resonance imaging) and PET images in accelerator-based BNCT using the NeuPex system. The GTV (gross tumor volume) was defined based on MRI (GTV) and PET images with SUV thresholds of 2.
View Article and Find Full Text PDFPhys Med
August 2025
Department of Energy, Politecnico di Milano, Milan 20133, Italy. Electronic address:
Background: Boron Neutron Capture Therapy (BNCT) selectively targets tumor cells while sparing healthy ones, by exploiting neutron capture on boron-10, which accumulates to the cancerous cells. To ensure that the therapy is properly tuned, real-time dose monitoring during treatment plays a fundamental role. A Single Photon Emission Computed Tomography (SPECT) imaging system relying on the 478 keV gamma ray emitted by the neutron capture reaction, can, in principle, detect the boron distribution and allow the 3D reconstruction of the dose inside the patient.
View Article and Find Full Text PDFJ Radiat Res
July 2025
National Metrology Institute of Japan (NMIJ), National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1 Umezono, Tsukuba, Ibaraki 305-8568, Japan.
An optical fiber-based neutron detector is a real-time neutron monitor for an intense neutron field. A small piece of neutron scintillator, such as Ce-doped lithium glass (Li-glass), used in the detector has a random shape with a grain size of 200-400 μm. This causes shape-dependent effects on the detector response.
View Article and Find Full Text PDFInt J Cancer
July 2025
Department of Chemistry, University of Helsinki, Helsinki, Finland.
Boron neutron capture therapy (BNCT) is an innovative radiation oncology approach that targets tumors selectively, minimizing damage to healthy tissues through high-linear-energy-transfer particles released during the boron neutron capture reaction. Current boron carriers like sodium mercaptoundecahydrododecaborate (BSH) and L-p-boronophenylalanine (BPA) face limitations in specificity and solubility. Our recently developed 6-O-(o-carboranylmethyl)-d-glucopyranose (B-Glc) shows promise as an alternative, demonstrating strong interactions with glucose transporters in human head and neck squamous cell carcinoma (HNSCC) CAL 27 cells in vitro.
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