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One-sixth of the global terrestrial surface now falls within protected areas (PAs), making it essential to understand how far they mitigate the increasing pressures on nature which characterize the Anthropocene. In by far the largest analysis of this question to date and not restricted to forested PAs, we compiled data from 12,315 PAs across 152 countries to investigate their ability to reduce human pressure and how this varies with socioeconomic and management circumstances. While many PAs show positive outcomes, strikingly we find that compared with matched unprotected areas, PAs have on average not reduced a compound index of pressure change over the past 15 y. Moreover, in tropical regions average pressure change from cropland conversion has increased inside PAs even more than in matched unprotected areas. However, our results also confirm previous studies restricted to forest PAs, where pressures are increasing, but less than in counterfactual areas. Our results also show that countries with high national-level development scores have experienced lower rates of pressure increase over the past 15 y within their PAs compared with a matched outside area. Our results caution against the rapid establishment of new PAs without simultaneously addressing the conditions needed to enable their success.
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http://dx.doi.org/10.1073/pnas.1908221116 | DOI Listing |
Diabetologia
September 2025
Department of Diabetology and Internal Medicine, Medical University of Warsaw, Warsaw, Poland.
This review article, developed by the EASD Global Council, addresses the growing global challenges in diabetes research and care, highlighting the rising prevalence of diabetes, the increasing complexity of its management and the need for a coordinated international response. With regard to research, disparities in funding and infrastructure between high-income countries and low- and middle-income countries (LMICs) are discussed. The under-representation of LMIC populations in clinical trials, challenges in conducting large-scale research projects, and the ethical and legal complexities of artificial intelligence integration are also considered as specific issues.
View Article and Find Full Text PDFJ Physician Assist Educ
September 2025
Chris Gillette, PhD, is a professor and director of Research and Scholarship, Department of PA Studies and also a professor of Department of Epidemiology and Prevention at Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Introduction: There has long been a shortage of health care providers in rural areas. Interventions that have been shown to increase rural recruitment have yet to be explored in physician associates (PAs). This study seeks to identify the association between PA training site and first job location.
View Article and Find Full Text PDFBull Cancer
September 2025
Réanimation médicale et chirurgicale, groupe hospitalier Paris Saint-Joseph, 185, rue R.-Losserand, 75674 Paris, France; Research/Reflexion on End of life support Quality in Everyday Medical Practice (REQUIEM) Study Group, Paris, France. Electronic address:
Background: The prevalence of cancers and hematological malignancies is high and continues to grow. The severity of these pathologies calls for patients to be given the opportunity to express their values, particularly with regard to the intensity of treatment and the type of care they wish to receive. However, the prevalence of advance directives (ADs) in this population remains low.
View Article and Find Full Text PDFEncephale
September 2025
Speech and Language Pathology Department of Nice, Faculty of Medicine, Campus Pasteur, université Côte d'Azur, 28, avenue de Valombrose, 06107 Nice, France; Cognition Behaviour Technology Laboratoy (CoBTeK), institut Claude-Pompidou, université Côte d'Azur, 10, rue Molière, 06000 Nice, France.
Introduction: Apathy, commonly observed in neurocognitive disorders, is characterized by a reduction in goal-directed behavior with a reduction of initiatives interests and emotions. This article presents the case of Mrs. B.
View Article and Find Full Text PDFEncephale
September 2025
Département de psychiatrie de l'adolescent et du jeune adulte, institut mutualiste Montsouris, 42, boulevard Jourdan, Paris, France; UVSQ, Inserm U1178, PsyDev, CESP université Paris-Saclay, Villejuif, France; Université Paris-Cité, Paris, France.
The body of knowledge on trauma is rapidly expanding. Since 2022, the WHO has been calling for the history of adversity to be systematically taken into account when assessing the state of health of all individuals. But at this stage, our understanding of the precise mechanisms of complex trauma remains incomplete.
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