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| http://dx.doi.org/10.1016/j.nefro.2019.05.003 | DOI Listing |
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Granulomatosis with polyangiitis (GPA), formerly known as Wegener's granulomatosis, is a rare form of pauci-immune vasculitis that primarily affects the respiratory tract and kidneys, though it can involve virtually any organ system. As a systemic vasculitis, it targets small- and medium-sized blood vessels and is associated with anti-neutrophil cytoplasmic antibodies (ANCA), particularly those directed against proteinase 3 (PR3). Due to its nonspecific symptoms and variable clinical presentation, GPA requires a high index of suspicion for timely diagnosis.
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Eisenhower Medical Center, Rancho Mirage, CA, USA.
Tubulointerstitial nephritis (TIN) is an inflammatory infiltrate of interstitial kidney most commonly caused by infections, drugs, allergies, and a number of autoimmune conditions. In this case, we have a 40-year-old male who was thought to have post-streptococcal glomerulonephritis given his symptoms of sore throat and pharyngitis before having renal involvement; however, after further evaluation was found to have biopsy proven interstitial nephritis without glomerular involvement. We note that TIN has multiple etiologies, and in our patient, we believe the combination of sore throat and pharyngitis attributed to and the concomitant nonsteroidal anti-inflammatory drug use and eventual bacterial translocation into the bloodstream, led to all the atypical manifestations described in this study.
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Introduction/objectives: Eosinophilic granulomatosis with polyangiitis (EGPA) is a necrotizing vasculitis that frequently affects small arteries in the skin and the nerve but can also involve the medium-sized arteries, resembling polyarteritis nodosa (PAN). This study aimed to evaluate the clinical value of biomarkers in EGPA in relation to the size of the affected arteries.
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Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, Tokyo, Japan.
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