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http://dx.doi.org/10.1093/rap/rkz019 | DOI Listing |
Curr Opin Rheumatol
September 2025
Division of Rheumatology, Department of Internal Medicine.
Purpose Of Review: This review explores the evolving understanding of vascular dysfunction in systemic sclerosis (SSc), from early endothelial injury to clinical manifestations and emerging therapeutic strategies.
Recent Findings: Endothelial cell (EC) injury, senescence, and endothelial-to-mesenchymal transition are central to SSc vasculopathy. Single-cell and spatial omics have revealed distinct EC subtypes and dysregulated pathways, including interferon signaling and chromatin remodeling.
Rheumatology (Oxford)
September 2025
Department of Experimental and Clinical Medicine, Division of Rheumatology, University of Florence, Florence, Italy.
Objectives: To describe the prevalence of gastrointestinal (GI) symptoms in systemic sclerosis (SSc) and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement, and explore a cranio-caudal pattern of symptom distribution, using data from the Italian SPRING-SIR registry.
Methods: This cross-sectional analysis included patients fulfilling 2013 ACR/EULAR SSc or VEDOSS criteria. GI involvement was defined as symptoms in at least one GI tract segment and categorized as upper and lower.
Curr Rheumatol Rev
August 2025
Sivas Cumhuriyet University Faculty of Medicine, Sivas, Turkey.
Introduction: Systemic sclerosis is a complex autoimmune disease characterized by diverse clinical manifestations that vary among individuals. It is associated with significant morbidity and mortality. This study aimed to evaluate the existing literature on the use of capillaroscopy in systemic sclerosis and to perform a bibliometric analysis.
View Article and Find Full Text PDFClin Pract
August 2025
Internal Medicine Unit, ASST Ovest Milanese, Legnano Hospital, Via Papa Giovanni Paolo II, Legnano, 20025 Milan, Italy.
Digital ulcers (DUs) are among the most debilitating vascular complications in SSc and are commonly attributed to microvascular damage. However, recent evidence suggests a potential involvement of macrovascular abnormalities, including subclinical atherosclerosis and altered hemodynamic parameters. This study aimed to investigate the association between a history of DUs and macrovascular involvement in SSc patients through carotid and vertebral Doppler ultrasonography, with a focus on hemodynamic indices such as Peak Systolic Velocity (PSV), End-Diastolic Velocity (EDV), Resistive Index (RI), and Intima-Media Thickness (IMT).
View Article and Find Full Text PDFJ Scleroderma Relat Disord
August 2025
The University of Melbourne, Melbourne, VIC, Australia.
Background: Functional disability is a major concern for individuals with systemic sclerosis (SSc). The Health Assessment Questionnaire-Disability Index (HAQ-DI) measures the ability to perform activities of daily living, with higher scores indicating poorer function.
Objective: To define the frequency and clinical associations of minimum clinically important difference (MCID) change in HAQ-DI scores in SSc.