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Protected areas (PAs) are the leading tools to conserve forests. However, given their mixed effectiveness, we want to know when they have impacts internally and, if they do, when they have spillovers. Political economy posits roles for the level of government. One hypothesis is that federal PAs avoid more internal deforestation than state PAs since federal agencies consider gains for other jurisdictions. Such political differences as well as economic mechanisms can cause PA spillovers to vary greatly, even from "leakage," more deforestation elsewhere, to "blockage," less deforestation elsewhere. We examine internal impacts and local spillovers for Brazilian Amazon federal and state agencies. Outside the region's "arc of deforestation," we confirm little internal impact and show no spillovers. In the "arc," we test impacts by state, as states are large and feature considerably different dynamics. For internal impacts, estimates for federal PAs and indigenous lands are higher than for state PAs. For local spillover impacts, estimates for most arc states either are not significant or are not robust; however, for Pará, federal PAs and indigenous lands feature both internal impacts and local spillovers. Yet, the spillovers in Pará go in opposite directions across agencies, leakage for indigenous lands but blockage for federal PAs, suggesting a stronger external signal from the environmental agency. Across all these tools, only federal PAs lower deforestation internally and nearby. Results suggest that agencies' objectives and capacities are critical parts of the contexts for conservation strategies.
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http://dx.doi.org/10.1073/pnas.1802877116 | DOI Listing |
Soins
September 2025
Ramsay Santé, 39 rue Mstislav-Rostropovitch, 75017 Paris, France. Electronic address:
Since the submission of the report on the health of healthcare professionals in 2023, this subject has become part of the public debate. The health crisis was a powerful reminder of the importance of improving and preserving the health of health and social care professionals. Today, this has become an object of research and action in its own right, with numerous initiatives being structured and federated across the region.
View Article and Find Full Text PDFJ Comput Chem
September 2025
Johnson & Johnson, Beerse, Belgium.
Herein we report the in silico discovery of 13 novel micromolar potent inhibitors of the SARS-CoV-2 NSP13 helicase validated in cellular antiviral and biophysical ThermoFluor assays. The compounds, discovered using a novel fragment-based pharmacophore virtual screening workflow named FragmentScout, enable the advancement of novel antiviral agents. FragmentScout uses publicly accessible structural data of the SARS-CoV-2 NSP13 helicase, which was previously generated at the Diamond LightSource by XChem high-throughput crystallographic fragment screening.
View Article and Find Full Text PDFMil Med
August 2025
National Commission on Certification of Physician Assistants, 12000 Findley Road, Suite 200, Johns Creek, GA 30097, United States.
Objective: Physician assistants/associates (PAs) serve as commissioned medical officers in the uniformed services, supporting readiness, global health operations, and domestic response. Despite their critical contributions, limited data exist to inform strategic workforce planning, recruiting, and retention efforts.
Materials And Methods: A cross-sectional quantitative analysis was conducted using a 2023 national workforce dataset.
Clin Pract
August 2025
Department of Medicine, Nephrology Division, Federal University of São Paulo, São Paulo 04038-031, SP, Brazil.
: Renal malacoplakia is a rare chronic granulomatous disease, often associated with immunosuppression and persistent Gram-negative infections, particularly . : We present a case involving a 31-year-old woman with hypertension, gestational diabetes, and prior uterine curettage after labor induction for preeclampsia at 23 weeks. She developed urinary sepsis post-procedure.
View Article and Find Full Text PDFNat Rev Endocrinol
August 2025
Institute of Endocrine and Metabolic Sciences, Università San Raffaele Vita-Salute, IRCCS Ospedale San Raffaele, Milan, Italy.
The 15th Acromegaly Consensus Conference in September 2023 updated recommendations on therapeutic outcomes for acromegaly. Since the publication of medical management guidelines in 2018, new pharmacological agents and new treatment approaches have been developed. Fifty-two experts in the management of acromegaly reviewed the current literature and assessed changes in drug approvals, clinical practice standards and management.
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