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Article Abstract
Background: The B Prognostic Score (BPS) is a clinical decision-making tool in metastatic breast cancer (MBC) that provides risk classification based on routine parameters. This study validates the BPS in an independent series of MBC for the whole study group and for each intrinsic subtype.
Patients And Methods: We analyzed 641 metastasized patients, treated in 17 German certified breast cancer centers between 2001 and 2009. They were classified into low, intermediate, and high-risk groups according to BPS. Overall survival (OS) curves for the various BPS groups were compared with Kaplan-Meier method.
Results: According to the BPS formula, 42.3% of patients were classified as low risk, 25.4% as intermediate risk and 32.3% as high risk. Intermediate- and high-risk patients had a statistically significant decreased OS compared with BPS low-risk patients: (intermediate-risk: hazard ratio, 1.36; 95% confidence interval, 1.04-1.77; P = .023; high-risk: hazard ratio, 2.62; 95% confidence interval, 2.06-3.32; P < .001). The 5-year survival rates of low-, intermediate-, and high-risk patients were 41.3%, 26.9%, and 10.2%, respectively. The distribution of BPS risk groups varied significantly within the intrinsic subtypes. For each intrinsic subtype, BPS gives an additional risk classification.
Conclusions: This study demonstrates the reproducibility of the BPS based on routinely assessable parameters and confirms its prognostic value in an independent entire cohort of MBC as well as in the separate intrinsic subtypes. It therefore can help in counseling and individualizing the therapeutic regimens of those patients.
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| http://dx.doi.org/10.1016/j.clbc.2019.04.015 | DOI Listing |
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