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Our high-fidelity simulation model provides a realistic example for health-care professionals to experience cannulation, initiation, and hemodynamic stabilization during extracorporeal membrane oxygenation (ECMO) therapy. This educational experience brings a variety of critical care specialties together, in a controlled simulation setting, to develop, master, and maintain clinical skills. This may include perfusionists, ECMO specialists, surgical technicians, registered nurses, physicians, and students. The simulation component includes a unique vascular access pad that is attached to either a static fluid model or to the Califia perfusion simulator system (Biomed Simulation, Inc., San Diego, CA). This collective high-fidelity simulation model can be surgically cannulated via a cutdown technique using an appropriately sized cannula and connected to an in situ ECMO circuit. This article explains the educational strategy, how the surgical pad is made, and the simulator connections so that any hospital can re-create this experience.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6586262 | PMC |
J Mol Histol
September 2025
Department of Cardiovascular Medicine, Jiangxi Provincial People's Hospital/The First Affiliated Hospital of Nanchang Medical College, Nanchang, 330006, China.
Robinin (RB) is an accepted antioxidant herbal product with known cardio-protective activity. To explore the anti-oxidative potential of RB in treating myocardial ischemia or reperfusion (MI/RI) damage in rats after inducing hypercholesterolemia (HC). HC was induced by administering cholesterol (2%) to rats for eight weeks.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
September 2025
Hematology and Transfusion Center, University of Campinas - UNICAMP, Campinas. São Paulo, Brazil. 13083-878.
Intravascular hemolysis (IVH), a pathological process associated with various conditions, triggers inflammatory responses, yet the key molecular drivers of these responses are poorly defined, particularly within the vasculature. To explore the role of NLRP3 inflammasome- and caspase-1-dependent pathways in IVH-induced vascular dysfunction, we used models of acute and chronic IVH, alongside heme stimulation of endothelial cells, thereby isolating this disease mechanism from its etiological causes. IVH induced rapid inflammatory responses in C57BL/6J mice, including IL-1β release within 15 minutes, and NLRP3-dependent caspase-1 activation in circulating leukocytes.
View Article and Find Full Text PDFMagn Reson Med Sci
September 2025
Department of Radiology, University of California-San Diego, La Jolla CA, USA.
Purpose: This study aims to extend the general kinetic model (GKM) for perfusion signal analysis using multi-pulsed arterial spin labeling (mPASL) acquisitions with multiple post-labeling delays (mPLD). The approach aims to improve accuracy and gain potential for broader experimental and clinical applications.
Methods: The magnetization vector evolution of the mPASL technique was analyzed using sequence diagrams and numerical simulation, supplemented by static phantom experiments.
IEEE Trans Biomed Eng
September 2025
Objective: Imposing accurate outflow boundary conditions remains a significant challenge in 3D computational fluid dynamics simulations of patient-specific cerebral blood flow. Widely used Windkessel models often rely solely on geometric factors, such as outlet numbers and diameters, leading to inaccuracies caused by image quality limitations and simplified vessel representations. This preliminary study proposes a novel functional region-based approach to enhance the accuracy of cerebral blood flow simulations.
View Article and Find Full Text PDFYonsei Med J
September 2025
The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Purpose: Ex vivo machine perfusion (EVMP) is increasingly recognized as a promising technique for enhancing the preservation and viability of donor organs, particularly in donation after circulatory death (DCD) liver transplantation (LT). This study validates a transplant surgeon-innovated EVMP protocol by assessing its efficacy in preserving liver function and reducing ischemia-reperfusion injury (IRI) in a porcine DCD-simulated liver transplant (DCD sLT) model.
Materials And Methods: Twenty Yorkshire pigs were used to compare static cold storage (SCS) and EVMP.