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We report a case of an elderly woman on polypharmacy who developed appetite loss, general fatigue and muscle weakness mainly from secondary adrenal insufficiency caused by quitting one semiregular single-dose medicine. Because the degree of insufficiency was mild, her symptoms were eliminated after some time without additional treatment. The present case includes important lessons related to medication management in elderly patients. Additionally, the present case also warns us to be cautious while diagnosing geriatric syndromes as a part of the physiological aging process or additional disease symptoms. Drug-induced geriatric syndrome from quitting semiregular-use drugs should be investigated in future studies.
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http://dx.doi.org/10.1093/omcr/omz047 | DOI Listing |
Maturitas
September 2025
Department of Geriatrics, National Clinical Research Center for Geriatric Diseases, Xuanwu Hospital Capital Medical University, Beijing, China; Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China. Electronic address:
Background: Falls are a major cause of disability. Whether exposure to ambient air pollution contributes to the occurrence of falls remains unclear.
Objective: To investigate the cross-sectional and longitudinal associations between ambient air pollution and the risk of falls in a community-dwelling adult population.
Pigment Cell Melanoma Res
September 2025
Department of Dermatology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
The diagnostic approaches for Hermansky-Pudlak Syndrome (HPS) include genetic sequencing, immunoblotting, electron microscopy (EM), and flow cytometry with mepacrine staining. However, these methods are often impractical for routine clinical use due to high cost, technical complexity, and limited availability. In this study, we evaluated dense granules (DGs) function in HPS mouse models using flow cytometry with mepacrine and FluoZin-3 staining.
View Article and Find Full Text PDFInn Med (Heidelb)
September 2025
Comprehensive Cancer Center, Universitätsklinik Würzburg, Würzburg, Deutschland.
Frailty is a common geriatric syndrome in older patients with cancer. It affects prognosis and treatment tolerance in various ways. Frailty and cancer share several common risk factors, which are reflected in the hallmarks of aging.
View Article and Find Full Text PDFFront Med (Lausanne)
August 2025
Department of Anesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Würzburg, Würzburg, Germany.
Unlabelled: Bleeding and thromboembolic events (BTE) increase the mortality of COVID-19 acute respiratory distress syndrome (ARDS) treated with extracorporeal membrane oxygenation (ECMO). The current analysis aimed to assess frequency and determinants of BTE according to their location and severity in a retrospective analysis of the German ECMO COVID-19 registry. Logistic regression was applied to identify factors influencing ICU survival as well as variables associated with risks of BTE.
View Article and Find Full Text PDFMed Sci Monit
September 2025
Department of Geriatric Nursing, Medical University of Warsaw, Warsaw, Poland.
BACKGROUND Frailty syndrome (FS) and cognitive impairment are major geriatric concerns, particularly prevalent among hospitalized older adults. The primary objective of this study was to assess the co-occurrence of FS and cognitive impairment in hospitalized geriatric patients. Additionally, the study analyzed the relationship of these conditions with functional status, fall risk, sensory deficits, depressive symptoms, and selected prognostic laboratory parameters.
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