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Article Abstract

People who are engineering biological organisms often find it useful to communicate in diagrams, both about the structure of the nucleic acid sequences that they are engineering and about the functional relationships between sequence features and other molecular species . Some typical practices and conventions have begun to emerge for such diagrams. The Synthetic Biology Open Language Visual (SBOL Visual) has been developed as a standard for organizing and systematizing such conventions in order to produce a coherent language for expressing the structure and function of genetic designs. This document details version 2.1 of SBOL Visual, which builds on the prior SBOL Visual 2.0 standard by expanding diagram syntax to include methods for showing modular structure and mappings between elements of a system, interactions arrows that can split or join (with the glyph at the split or join indicating either superposition or a chemical process), and adding new glyphs for indicating genomic context (e.g., integration into a plasmid or genome) and for stop codons.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6798824PMC
http://dx.doi.org/10.1515/jib-2018-0101DOI Listing

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Article Synopsis
  • * The introduction of the Synthetic Biology Open Language Visual (SBOLv) allows bioengineers to visually share biological designs, but maintaining the numerous glyphs in the standard poses challenges for tool development.
  • * The Python package paraSBOLv simplifies the creation of SBOLv diagrams with parametric glyph definitions, promoting faster development of biodesign tools and suggesting that adopting these definitions in the SBOLv standard could ease future tool creation and visual integration.
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People who engineer biological organisms often find it useful to draw diagrams in order to communicate both the structure of the nucleic acid sequences that they are engineering and the functional relationships between sequence features and other molecular species. Some typical practices and conventions have begun to emerge for such diagrams. SBOL Visual aims to organize and systematize such conventions in order to produce a coherent language for expressing the structure and function of genetic designs.

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