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Cavernous malformations (cavernomas) of the brain stem with recurrent hemorrhage may be amenable to microsurgical resection if they are present close to the surface. The risks of surgery need to be balanced with the natural history of the lesion and the accumulation of neurological deficits and risk to life with multiple hemorrhages. In this 3D operative video, we illustrate the technique for the resection of a dorsally located midbrain cavernous malformation. Informed consent was obtained for this procedure. The cavernoma is accessed with the use of a supracerebellar infratentorial approach. The infratentorial craniotomy and coagulation of the superior vermian veins is shown. A description is provided of the use of hemosiderin staining and the intercollicular relative "safe zone"1 as landmarks for the neurotomy. The technique of cavernoma dissection from the surrounding gliotic plane is shown and described. In this case, the patient required prolonged rehabilitation but fully recovered without residual deficit 1 yr following surgery.
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http://dx.doi.org/10.1093/ons/opz114 | DOI Listing |
Diagnostics (Basel)
August 2025
Institute of Diagnostic Radiology, Pauls Stradins Clinical University Hospital, 13 Pilsonu Street, LV-1002 Riga, Latvia.
: Hypertrophic olivary degeneration (HOD) is a rare form of trans-synaptic degeneration involving the Guillain-Mollaret triangle, characterized by enlargement of the inferior olivary nucleus-unlike the atrophy typical of most neurodegenerative processes. It is usually associated with stroke, surgical injury, or demyelination, but rarely follows hemorrhage from a cavernous malformation (CM). This report presents a case of HOD secondary to a mesencephalic CM hemorrhage, with emphasis on imaging findings and diagnostic considerations.
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April 2025
Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai, China; Cancer Center, Shanghai Zhongshan Hospital, Fudan University, Shanghai, China; Digital Medical Research Center, Fudan University, Shanghai, China. Electronic address:
Objective: Neurosurgical management of dorsal pontomesencephalic junction lesions is inherently complex and challenging. We introduce a novel endoscopic technique for resection of such lesions: the contralateral occipital interhemispheric transtentorial superior transvelar approach.
Methods: A meticulous dissection of 5 formalin-fixed cadaveric specimens was conducted to simulate the contralateral occipital interhemispheric transtentorial superior transvelar approach, with a focus on exposing the pontomesencephalic junction and the upper fourth ventricle.
Surg Radiol Anat
February 2025
Neuroradiology Unit, Azienda Unità Sanitaria Locale-IRCCS di Reggio Emilia, Reggio Emilia, Italy.
Purpose: The Basal Vein of Rosenthal (BVR) is one of the most stable intracranial veins. Despite this, several anomalies have been described and are related to its embryological origin as a longitudinal vein generated by the anastomosis between different segments. The anatomical variability also accounts for the presence and activation of different functional drainage pathways, both anteriorly and posteriorly, as well as with anastomoses with the infratentorial venous system METHODS: We are presenting an incidental finding in a patient undergoing brain Magnetic Resonance Imaging (MRI) in the diagnostic work-up of endolymphatic hydrops.
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January 2025
Department of Neurosurgery, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Background: Cavernous malformations are common vascular abnormalities of the central nervous system, but cavernous malformations of the cerebral aqueduct are rare. The choice of treatment is influenced by various factors.
Case Description: We report two cases of midbrain cavernous malformations.
World Neurosurg
March 2025
Department of Neurosurgery, Altınbaş University, Istanbul, Turkiye. Electronic address:
Brainstem cavernous malformations are relatively rare lesions with a higher tendency of hemorrhage than supratentorial cavernous malformations. Due to the compact arrangement of fiber tracts and nuclei of the region, any hemorrhagic event can cause severe neurological deficits. This eloquent architecture of the area also makes any surgical attempt challenging.
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