Osteoprotegerin and osteopontin levels, but not gene polymorphisms, predict mortality in cardiovascular diseases.

This study aims to investigate whether osteoprotegerin (OPG) or osteopontin (OPN) single nucleotide polymorphisms (SNPs) will predict survival. This study enrolled 617 participants undergoing health examination, 536 coronary artery disease (CAD) patients and 86 peripheral artery disease (PAD) patients. Genotypes of SNP rs2073618 and SNP rs11730582 were determined. OPG and OPN levels were measured. In both CAD and PAD populations, high OPG and OPN levels were strong predictors of all-cause death. The rs2073618 CC genotype and the rs11730582 TT genotype did not predict mortality. High OPG and high OPN levels, but not rs2073618 CC genotype or rs11730582 TT genotype, were strong predictors of mortality in both CAD and PAD patients.