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Purpose Of Review: Concern regarding appendicitis is a common reason for presentation to the paediatric emergency department. We review recent progress in the use of biomarkers, imaging and clinical scoring systems in improving diagnostic accuracy in suspected appendicitis in children.
Recent Findings: Use of ultrasound, often performed at the bedside, is becoming more widespread with a parallel reduction in computed tomography (CT) use. Protocols for image acquisition and interpretation have been shown to improve diagnostic accuracy. Novel biomarkers have been explored and clinical diagnostic algorithms refined but none have achieved the level of diagnostic accuracy required.
Summary: Appendicitis remains a clinical diagnosis. Point of care ultrasound is increasingly available and offers higher diagnostic accuracy than several routinely performed laboratory investigations. Recent publications provide support for increased use of clinician performed ultrasound, increased use of MRI, less use of CT, less emphasis on basic laboratory investigation and a renewed respect for the value of serial examination, particularly early in the course of illness.
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http://dx.doi.org/10.1097/MOP.0000000000000749 | DOI Listing |
Acad Radiol
September 2025
Department of Radiology, Başakşehir Çam and Sakura City Hospital, Istanbul, Turkey (E.E.).
Purpose: This study aimed to evaluate the performance of ChatGPT (GPT-4o) in interpreting free-text breast magnetic resonance imaging (MRI) reports by assigning BI-RADS categories and recommending appropriate clinical management steps in the absence of explicitly stated BI-RADS classifications.
Methods: In this retrospective, single-center study, a total of 352 documented full-text breast MRI reports of at least one identifiable breast lesion with descriptive imaging findings between January 2024 and June 2025 were included in the study. Incomplete reports due to technical limitations, reports describing only normal findings, and MRI examinations performed at external institutions were excluded from the study.
Nihon Hoshasen Gijutsu Gakkai Zasshi
September 2025
Department of Radiological Technology, Faculty of Health Sciences, Gifu University of Medical Science.
Purpose: We aimed to develop an AI-based system to score the positioning in mammography (MG), with the goal of establishing a foundation for future technical support.
Methods: Using 800 mediolateral oblique (MLO) images, we developed an AI model (Mask Generation Model) for automatic extraction of three regions: the pectoralis major muscle, the mammary gland region, and the nipple. Using this model, we extracted three regions from 1544 MLO images and generated mask images.
Infect Dis Clin North Am
September 2025
Division of Gastroenterology & Hepatology, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address:
This article offers a clinically focused overview of Clostridioides difficile infection (CDI) diagnosis, emphasizing the need to test only symptomatic patients and to distinguish true infection from colonization. It reviews multistep diagnostic algorithms that pair glutamate dehydrogenase (GDH) testing or nucleic acid amplification tests (NAAT) with toxin assays to improve accuracy. The limitations of PCR-only approaches are discussed, with a strong emphasis on clinical correlation.
View Article and Find Full Text PDFRen Fail
December 2025
Department of Nephrology, The First Hospital of Jilin University, Changchun, China.
Background: Inflammation and hyperuricemia are closely associated with chronic kidney disease (CKD). The systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR) are emerging as novel biomarkers. While, the synergistic effects of these biomarkers with hyperuricemia on CKD remain unclear.
View Article and Find Full Text PDFAnal Chim Acta
November 2025
Marine Engineering College, Dalian Maritime University, Dalian, 116026, China. Electronic address:
On-site and accurately detecting, sizing and counting living algae are greatly needed under International Ballast Water Convention, yet still challenging due to the lack of miniatured device. In this paper, a miniatured microscope that has both blue view field and fluorescence field was developed. Dual-view-field with one exciting light is achieved by using a beam splitter to direct the light into two mini cameras.
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