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http://dx.doi.org/10.1542/pir.2018-0223 | DOI Listing |
Pediatr Allergy Immunol
August 2025
Department of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Background: The increase of allergies is attributed to a multi-factorial pathogenesis. Multi-gene traits, as well as different environmental factors, are regarded as responsible for shaping the development of atopic entities. The microbiome's composition in particular seems to play a decisive role in allergy prevention and immunological defense.
View Article and Find Full Text PDFPediatr Allergy Immunol
August 2025
Allergy Immunology, Murdoch Children's Research Institute, Parkville, Victoria, Australia.
Background: The high burden of peanut allergy underscores the need for treatment options that improve patient health-related quality of life (HRQL). However, the modifying effect of sex assigned at birth on treatment-related outcomes remains poorly understood. We sought to investigate whether sex modifies treatment effect on the change in overall and subdomain HRQL during the PPOIT-003 trial.
View Article and Find Full Text PDFBr J Dermatol
August 2025
Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Department of Dermatology, Venereology and Allergology, Center of Experimental and Applied Cutaneous Physiology, Berlin, Germany.
Background: In Europe, 1-2% of children are diagnosed with a peanut allergy. Atopic dermatitis (AD) is a significant risk factor for food allergy development, with cutaneous allergen exposure playing a causative role in allergic sensitization, particularly in early childhood.
Objectives: To investigate the primary and secondary skin-to-skin transfer of peanut proteins and the impact of hand washing in reducing allergen transfer.
J Food Allergy
August 2024
Departments of Medicine and Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire; and.
Background: Anaphylaxis is a serious systemic hypersensitivity reaction that is rapid in onset and may cause death.
Methods: The true prevalence of infant anaphylaxis is unknown, but such cases may be increasing in presentation of these patients to emergency departments, with studies that evaluate health-care utilization after implementation of early introduction guidelines that report an increase in the use of emergency department for food-related visits as well as an increase in epinephrine prescriptions for infants.
Results: Reasons for these increases may include early food introduction as well as therapeutic interventions such as early life or preschool oral immunotherapy.
Pediatr Allergy Immunol
August 2025
Département des sciences fondamentales, Université du Québec à Chicoutimi, Saguenay, Quebec, Canada.
Background: Food allergies (FAs) are an increasing public health concern, particularly in children. Oral immunotherapy (OIT) is an emerging treatment strategy under clinical investigation for desensitization of children with FA to food allergens. Dysbiosis of the gut microbiota has been implicated in FAs, and various factors influence its composition; however, the impact of OIT on the gut microbiota remains largely unexplored.
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