Associations of Common Variants in and Genes with Hepcidin-25 and Iron Status Parameters in Patients with End-Stage Renal Disease.

Background: Influence of A736V and (C282Y and H63D) polymorphisms on serum hepcidin-25 levels and iron status parameters in end-stage renal disease (ESRD) patients stratified according to gender has not been previously investigated. In addition, we aimed to evaluate the diagnostic accuracy of the parameters to separate iron-deficiency anemia (IDA) from anemia of chronic disease.

Materials And Methods: Iron status parameters and genetic analysis were performed in 126 ESRD patients and in 31 IDA patients as the control group.

Results: ESRD patients had significantly higher ferritin and hepcidin-25 (<0.001) relative to IDA patients. Cut-off values with the best diagnostic accuracy were found for hepcidin ≥9.32 ng/mL, ferritin ≥48.2 g/L, transferrin saturation ≥16.8%, and MCV ≥81 fL. Interaction between gender and haplotypes for the hepcidin-25 and ferritin levels in ESRD patients ( = 0.005, partial eta squared = 0.09; = 0.027, partial eta squared = 0.06, respectively) was found. Serum transferrin was influenced by the combined effect of gender and A736V polymorphism in ESRD patients ( = 0.002, partial eta squared = 0.07).

Conclusion: Our findings could contribute to the further investigation of mechanisms involved in the pathophysiology and important gender-related involvement of the and polymorphisms on anemia in ESRD patients.