Effect of Citric Acid on Accuracy of C-Urea Breath Test after Eradication Therapy in a Region with a High Prevalence of Atrophic Gastritis.

Background/aims: The validity of C-urea breath test (C-UBT) for detection is influenced by atrophic gastritis. The aim of this study was to evaluate the effect of citric acid on the accuracy of C-Urea breath test after eradication therapy in a region where atrophic gastritis is common.

Methods: In this prospective study, -positive patients received C-UBT after eradication regimen. They were classified into citric acid group and control group. To determine diagnostic accuracy of C-UBT, patients were offered invasive methods.

Results: A total of 1,207 who successfully took -eradication regimen received UBT. They were assigned into the citric acid group (n=562) and the control group (n=645). The mean C-UBT value of the citric acid group was 10.3±26.4‰, which was significantly (p<0.001) higher than that of that control group (5.1‰±12.6‰). Of these patients 122 patients were evaluated by endoscopic biopsy methods. Based on invasive tests, the accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of C-UBT for the citric acid group were 83.3%, 91.7%, 81.3%, 55.0%, and 97.5%, respectively. Those of the control group were 87.7%, 90.9%, 88.2%, 62.5%, and 97.8%, respectively. They were not significantly different between the two groups. Although the presence of gastric atrophy and intestinal metaplasia (IM) decreased the accuracy, the decrease was not significant.

Conclusions: In a country with high prevalence of atrophic gastritis or IM, false positivity remained common despite the use of citric acid in C-UBT.