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To overcome the limitations of fast scan cyclic voltammetry (FSCV) to discriminate between catecholamines, we discuss new approaches to monitor the dynamics of these neurochemicals with high spatial, genetic, and temporal specificity.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6944310 | PMC |
http://dx.doi.org/10.1021/acschemneuro.9b00157 | DOI Listing |
JACC Case Rep
July 2025
Department of Cardiology, Hackensack Meridian Health, Jersey Shore University Medical Center, Neptune, New Jersey, USA.
Background: Takotsubo cardiomyopathy (TC) frequently co-occurs with spontaneous coronary artery dissection, but its co-occurrence with extracoronary arterial dissections is rare.
Case Summary: A 68-year-old woman with hypertension, hyperlipidemia, and type 2 diabetes reported lower abdominal pain and vomiting amid severe emotional distress. Within hours of admission to the hospital, she developed acute coronary syndrome and was diagnosed with TC, which was managed with dual antiplatelet therapy.
Sci Adv
July 2025
Department of Translational Neuroscience, Brain Center, UMC Utrecht, Utrecht University, Utrecht, Netherlands.
Adaptive responses to challenging environments depend on optimal function of the locus coeruleus (LC), the brain's main source of noradrenaline and primary mediator of the initial stress response. Combining functional circuit dissection and causal in vivo interventions in mice, we here investigate a built-in peptidergic regulatory system that restricts LC noradrenergic output. In particular, we characterize a population of neuropeptide Y (NPY)-expressing neurons surrounding LC noradrenergic cells.
View Article and Find Full Text PDFJ Headache Pain
June 2025
Sensory Biology Unit, Translational Research Centre, Copenhagen University Hospital- Rigshospitalet, Glostrup, Denmark.
Background: Calcitonin gene-related peptide (CGRP) release from trigeminal structures is central to migraine pathophysiology. This study employed an ex vivo model preserving anatomical continuity between the trigeminal nucleus caudalis (TNC) and trigeminal ganglion (TG) to investigate (1) whether TNC stimulation induces peripheral CGRP release from the TG and (2) the potential involvement of a distinct dopamine-endocannabinoid mechanism.
Methods: Tissues were dissected as a single unit and placed in custom 3D-printed chambers, allowing targeted stimulation of either the TNC or the TG while measuring CGRP in both compartments.
Int J Mol Sci
May 2025
Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Emerging evidence highlights the gut microbiota as a pivotal determinant of pharmacological efficacy. While ()-derived tyrosine decarboxylases () are known to decarboxylate levodopa (L-dopa), compromising systemic bioavailability, the causal mechanisms underlying microbiota-mediated pharmacodynamic variability remain unresolved. In our study, we employed antibiotic-induced microbiota depletion and fecal microbiota transplantation (FMT) to interrogate microbiota-L-dopa interactions in MPTP-induced Parkinson's disease (PD) mice.
View Article and Find Full Text PDFNeurosci Lett
July 2025
División de Neurociencias Básica, Instituto Nacional de Rehabilitación-LGII, Calzada México Xochimilco 289, Arenal de Guadalupe, Ciudad de México 14389, Mexico.
Pain is the most common and underdiagnosed non-motor symptom in Parkinson's disease. Dopaminergic receptors D2 and D5 have been implicated in pain modulation. In this study, the expression of D2 and D5 receptors in the midbrain and thalamus in response to a painful stimulus was evaluated.
View Article and Find Full Text PDF