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This paper introduces a new algorithm to estimate and perform inferences on a recently proposed and developed semiparametric generalized linear model (glm). Rather than selecting a particular parametric exponential family model, such as the Poisson distribution, this semiparametric glm assumes that the response is drawn from the more general exponential tilt family. The regression coefficients and unspecified reference distribution are estimated by maximizing a semiparametric likelihood. The new algorithm incorporates several computational stability and efficiency improvements over the algorithm originally proposed. In particular, the new algorithm performs well for either small or large support for the nonparametric response distribution. The algorithm is implemented in a new R package called .
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Stat Methods Med Res
September 2025
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands.
This study describes and compares the performance of several semi-parametric statistical modeling approaches to dynamically classify subjects into two groups, based on an irregularly and sparsely sampled curve. The motivating example of this study is the diagnosis of a complication following cardiac surgery, based on repeated measures of a single cardiac biomarker where early detection enables prompt intervention by clinicians. We first simulate data to compare the dynamic predictive performance over time for growth charts, conditional growth charts, a varying-coefficient model, a generalized functional linear model and longitudinal discriminant analysis.
View Article and Find Full Text PDFLancet
August 2025
Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea. Electronic address:
Background: Aspirin monotherapy is recommended indefinitely for patients with established coronary artery disease (CAD). The aim of this individual patient level meta-analysis was to provide a comprehensive evaluation of the comparative efficacy and safety of clopidogrel versus aspirin monotherapy in patients with established CAD, most of whom had undergone percutaneous coronary intervention or had acute coronary syndrome.
Methods: We conducted a systematic search in PubMed, Scopus, Web of Science, and Embase to identify randomised trials published from database inception to April 12, 2025, comparing clopidogrel monotherapy with aspirin monotherapy in patients with established CAD who had discontinued or never started dual antiplatelet therapy.
Clin Transplant
September 2025
Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida Health, Gainesville, Florida, USA.
Background: Hispanic/Latino individuals are the fastest growing subset of the US population. Although racial and ethnic differences in outcomes following lung transplantation have been recognized, they are not entirely understood. We compared long-term post-lung transplant outcomes in Hispanic/Latino and White non-Hispanic recipients and aimed to determine whether any differences are attributable to a specific racial-ethnic effect.
View Article and Find Full Text PDFBiom J
October 2025
Department of Mathematics and Statistics, University of Regina, Regina, Saskatchewan, Canada.
Partially linear models are commonly used in observational studies of the causal effect of treatment and/or exposure when there are observed confounding variables. The models are robust and asymptotically distribution-free for testing the causal null hypothesis. In this research, we investigate methods for estimating the partially linear models with data missing at random in all the variables, including the response, the treatment, and the confounding variables.
View Article and Find Full Text PDFJ Am Stat Assoc
February 2025
Department of Biostatistics, University of North Carolina at Chapel Hill, U.S.A.
In studies of chronic diseases, the health status of a subject can often be characterized by a finite number of transient disease states and an absorbing state, such as death. The times of transitions among the transient states are ascertained through periodic examinations and thus interval-censored. The time of reaching the absorbing state is known or right-censored, with the transient state at the previous instant being unobserved.
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