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http://dx.doi.org/10.1111/bjh.15840 | DOI Listing |
Int J Lab Hematol
June 2023
School of Biomedical Sciences, The University of Western Australia, Perth, Western Australia, Australia.
Myeloproliferative neoplasms (MPN) are a group of clonal haematological malignancies first described by Dameshek in 1957. The Philadelphia-negative MPN that will be described are polycythaemia vera (PV), essential thrombocythaemia (ET), pre-fibrotic myelofibrosis and primary myelofibrosis (PMF). The blood and bone marrow morphology are essential in diagnosis, for WHO classification, establishing a baseline, monitoring response to treatment and identifying changes that may indicate disease progression.
View Article and Find Full Text PDFImmunity
March 2020
Department of Host Defense, Research Institute for Microbial Diseases (RIMD), Osaka University, Osaka 565-0871, Japan; Laboratory of Host Defense, World Premier Institute Immunology Frontier Research Center (WPI-IFReC), Osaka University, Osaka 565-0871, Japan. Electronic address:
Fibrosis is an incurable disorder of unknown etiology. Segregated-nucleus-containing atypical monocytes (SatMs) are critical for the development of fibrosis. Here we examined the mechanisms that recruit SatMs to pre-fibrotic areas.
View Article and Find Full Text PDFBr J Haematol
July 2019
Mayo Clinic, Rochester, MN, USA.