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Background: The current studies investigated associations between pain intensity and pain frequency with loneliness, hostility, and social functioning using cross-sectional, longitudinal, and within-person data from community-dwelling adults with varying levels of pain.
Method: Secondary analysis of preexisting data was conducted. Study 1 investigated cross-sectional (baseline data: n = 741) and longitudinal (follow-up data: n = 549, observed range between baseline and follow-up: 6-53 months) associations. Study 2 tested within-person associations using daily diaries across 30 days from a subset of the participants in Study 1 (n = 69).
Results: Cross-sectionally, pain intensity and frequency were associated with higher loneliness (β = 0.16, β = 0.17) and worse social functioning (β = - 0.40, β = - 0.34). Intensity was also associated with higher hostility (β = 0.11). Longitudinally, pain intensity at baseline predicted hostility (β = 0.19) and social functioning (β = - 0.20) at follow-up, whereas pain frequency only predicted social functioning (β = - 0.21). Within people, participants reported higher hostility (γ = 0.002) and worse social functioning (γ = - 0.013) on days with higher pain, and a significant average pain by daily pain interaction was found for loneliness. Pain intensity did not predict social well-being variables on the following day.
Conclusion: Pain intensity and frequency were associated with social well-being, although the effects were dependent on the social well-being outcome and the time course being examined.
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http://dx.doi.org/10.1007/s12529-019-09776-5 | DOI Listing |
Brain Behav
September 2025
Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, Australia.
Background: Migraine pathophysiology involves a constellation of metabolic abnormalities. These interlinked contributory factors include mitochondrial dysfunction, an altered gut microbiome, neuroinflammation, oxidative stress, weight imbalance, and altered glucose metabolism. The ketogenic diet is an emerging therapy which may restore hypometabolism seen in chronic migraine.
View Article and Find Full Text PDFEur J Neurol
September 2025
Pain Treatment and Evaluation Center, CHU Timone, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
Background: Neuropathic pain (NP) is frequently resistant to conventional treatments. Botulinum toxin type A (BT-A) is a recommended option for focal peripheral NP, but the dynamics of its effect in real-life conditions remain poorly characterized.
Objective: To assess BT-A efficacy in a real-world study of patients with focal peripheral NP, over a 1-year follow-up period.
J Orthop Res
September 2025
Department of Kinesiology, College of Health Sciences, University of Rhode Island, Kingston, Rhode Island, USA.
Arthroplasty surgery is a common and successful end-stage intervention for advanced osteoarthritis. Yet, postoperative outcomes vary significantly among patients, leading to a plethora of measures and associated measurement approaches to monitor patient outcomes. Traditional approaches rely heavily on patient-reported outcome measures (PROMs), which are widely used, but often lack sensitivity to detect function changes (e.
View Article and Find Full Text PDFUrolithiasis
September 2025
Department of Urology, Icahn School of Medicine at Mount Sinai, 424 W. 59th Street, Suite 4F, New York, 10019, United States.
Introduction: High intrarenal pressures (IRP) during mini-PCNL have been postulated to result in increased postoperative pain but no studies have evaluated this to our knowledge. We sought to determine if there is a correlation between IRP and immediate postoperative pain when using different tract sizes.
Methods: Patients were enrolled and assigned for standard (s-PCNL, 24fr), suctioning-mini (sm-PCNL, 16fr) and non-suctioning-mini (nsm-PCNL, 17.
Clin Oral Investig
September 2025
Department of Endodontics, Faculty of Dentistry, Galala University, Suez, Egypt.
Objectives: Postoperative pain remains a significant concern in endodontics. The main aim of this clinical trial was to assess the impact of various obturation technique and sealer types on post-obturation pain and sealer extrusion in single-visit nonsurgical root canal treatments.
Materials And Methods: Study participants were recruited through consecutive sampling from patients referred to the Endodontic Department, Faculty of Dentistry, Institution University, diagnosed as asymptomatic irreversible pulpitis.