Category Ranking

98%

Total Visits

921

Avg Visit Duration

2 minutes

Citations

20

Article Abstract

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...].

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409840PMC
http://dx.doi.org/10.3390/v11020117DOI Listing

Publication Analysis

Top Keywords

human cytomegalovirus
8
drug repurposing
4
repurposing campaigns
4
campaigns human
4
cytomegalovirus identify
4
identify natural
4
natural compound
4
compound targeting
4
targeting immediate-early
4
immediate-early ie2
4

Similar Publications

Human cytomegalovirus (HCMV) infects up to 80% of the world's population. Here, we show that HCMV infection leads to widespread changes in human chromatin accessibility and chromatin looping, with hundreds of thousands of genomic regions affected 48 hr after infection. Integrative analyses reveal HCMV-induced perturbation of Hippo signaling through drastic reduction of TEAD1 transcription factor activity.

View Article and Find Full Text PDF

A woman, gravida 5, para 3, presented with fetal ascites at 19 weeks of gestation. Urinary ascites was initially suspected because of massive ascites and oligohydramnios; however, biochemical analysis of fetal ascites was inconsistent with this diagnosis. A peritoneal-amniotic shunt was placed to prevent pulmonary hypoplasia.

View Article and Find Full Text PDF

Introduction: The impact of race on outcomes of allogeneic hematopoietic cell transplants (HCT) has long been a field of research. The Center for International Blood and Marrow Transplant Research (CIBMTR) studies have shown worse survival for Black and Hispanic patients within the first year after HCT, but rates evened out for one-year survivors. From our personal experience, we hypothesize that the outcomes of South Asians (age ≥ 45 years) receiving myeloablative conditioning (MAC) are also worse compared to other races.

View Article and Find Full Text PDF

Development of a reverse genetics system for West Nile virus (Kunjin type).

Front Vet Sci

August 2025

Institute of Veterinary Medicine and Immunology, Sichuan Agricultural University, Chengdu, Sichuan, China.

Kunjin virus (KUNV), a naturally attenuated strain of West Nile virus (WNV), shares similar transmission modes and hosts-primarily mosquitoes, birds, and horses. Globally, reverse genetics is the principal methodology for characterizing the molecular etiology of flaviviruses. In this study, cytomegalovirus (CMV) promoter-driven KUNV reporter replicons were engineered to incorporate three distinct reporter genes: Nanoluc, oxGFP, and mCherry.

View Article and Find Full Text PDF

Diagnostic Challenges of Six-Pathogen Detected by mNGS in an Immunocompromised ICU Patient with Severe Community-Acquired Pneumonia-Induced Sepsis: A Case Report and Literature Review.

Infect Drug Resist

September 2025

Department of Emergency, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, 324000, People's Republic of China.

Introduction: Severe community-acquired pneumonia (SCAP) in immunocompromised patients is often caused by rare atypical pathogens, which are difficult to detect using conventional microbiological tests (CMTs) and can progress to sepsis in severe cases. Metagenomic next-generation sequencing (mNGS), an emerging pathogen detection technique, enables rapid identification of mixed infections and provides valuable guidance for clinical treatment decisions. SCAP-induced sepsis caused by a six-pathogen co-infection has not been previously reported, but interpretation remains a challenge.

View Article and Find Full Text PDF