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Article Abstract
A series of new angiotensin II receptor 1 antagonists were prepared. They displayed nanomolar affinity to AT receptor and could decrease blood pressure efficiently in spontaneously hypertensive rats. Among them, compounds and could reduce the blood pressure with more or equal potency compared to Losartan. So, compounds and could be considered as potential antihypertension drug candidates.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331155 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.8b00335 | DOI Listing |
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