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Objectives: The aims of this study were to: (1) measure the rate of failure to provide defect-free postoperative venous thromboembolism (VTE) chemoprophylaxis, (2) identify reasons for failure to provide defect-free VTE chemoprophylaxis, and (3) examine patient- and hospital-level factors associated with failure.
Summary Background Data: Current VTE quality measures are inadequate. VTE outcome measures are invalidated for interhospital comparison by surveillance bias. VTE process measures (e.g., SCIP-VTE-2) do not comprehensively capture failures throughout patients' entire hospitalization.
Methods: We examined adherence to a novel VTE chemoprophylaxis process measure in patients who underwent colectomies over 18 months at 36 hospitals in a statewide surgical collaborative. This measure assessed comprehensive VTE chemoprophylaxis during each patient's entire hospitalization, including reasons why chemoprophylaxis was not given. Associations of patient and hospital characteristics with measure failure were examined.
Results: The SCIP-VTE-2 hospital-level quality measure identified failures of VTE chemoprophylaxis in 0% to 3% of patients. Conversely, the novel measure unmasked failure to provide defect-free chemoprophylaxis in 18% (736/4086) of colectomies. Reasons for failure included medication not ordered (30.4%), patient refusal (30.3%), incorrect dosage/frequency (8.2%), and patient off-unit (3.4%). Patients were less likely to fail the chemoprophylaxis process measure if treated at nonsafety net hospitals (OR 0.62, 95% CI 0.39-0.99, P = 0.045) or Magnet designated hospitals (OR 0.45, 95% CI 0.29-0.71, P = 0.001).
Conclusions: In contrast to SCIP-VTE-2, our novel quality measure unmasked VTE chemoprophylaxis failures in 18% of colectomies. Most failures were due to patient refusals or ordering errors. Hospitals should focus improvement efforts on ensuring patients receive VTE prophylaxis throughout their entire hospitalization.
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http://dx.doi.org/10.1097/SLA.0000000000003124 | DOI Listing |
Appl Clin Inform
August 2025
Information Technology Services, UW Medicine, Seattle, Washington, United States.
Chemoprophylaxis reduces the risk of hospital-acquired venous thromboembolism (VTE), but is not reliably ordered. Our institution created a clinical decision support (CDS) interruptive alert to remind clinicians to order VTE chemoprophylaxis when it is missing for qualifying inpatients. Unfortunately, this alert has required repeated modifications to ensure accurate logic, and continues to generate negative feedback from users.
View Article and Find Full Text PDFJ Am Coll Surg
September 2025
Institute for Research on Equity and Community Health (iREACH), ChristianaCare Health System, Wilmington DE.
Background: There are no consensus guidelines demonstrating early venous thromboembolism prophylaxis (VTEP) is safe in patients with traumatic brain injury (TBI) who underwent neurosurgical interventions. We hypothesized that early initiation of VTEP in TBI patients would decrease the incidence of venous thromboembolism (VTE) and intracranial hemorrhage expansion (ICHE).
Study Design: A retrospective single center study of adult TBI patients who underwent neurosurgical intervention from 2012-2023 at a level 1 trauma center.
Foot Ankle Orthop
July 2025
Rutgers New Jersey Medical School, Newark, NJ, USA.
Background: The role of venous thromboembolism (VTE) chemoprophylaxis following ankle fracture surgery remains controversial. Although pharmacologic prophylaxis is standard in major orthopaedic procedures, its utility in foot and ankle trauma surgery is unclear because of low reported VTE rates and potential bleeding risks. Furthermore, no consensus exists on the cost-effectiveness of prophylactic agents in this population.
View Article and Find Full Text PDFAnn Otol Rhinol Laryngol
August 2025
Department of Otolaryngology, SUNY Upstate Medical University, Syracuse, USA.
Objectives: VTE is associated with significant morbidity and is the most common cause of preventable death in hospitalized patients. Although there are no society-specific guidelines for VTE prevention in otolaryngology, there is evidence to support routine use of chemoprophylaxis in high-risk patients. The objective of this study is to evaluate current methods of perioperative thromboprophylaxis.
View Article and Find Full Text PDFSurg Endosc
July 2025
Department of General Surgery, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Introduction: Venous thromboembolism (VTE) events, such as pulmonary embolism (PE) and deep venous thrombosis (DVT), are a significant source of morbidity and mortality after major abdominal wall reconstruction. We aim to describe the incidence of VTE events in patients undergoing ventral hernia repair (VHR) with transversus abdominis release (TAR) at our institution.
Methods: The Abdominal Core Health Quality Collaborative registry was queried for patients, 18 years and older, who underwent VHR with TAR at our institution between August 2014 and December 2023.