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Background: To prevent early postoperative dislocation following a total hip arthroplasty (THA) procedure, patients must adhere to restrictions. Restrictive protocols are common if THA surgery is performed using the posterior approach, but scientific evidence form larger studies that supports these restrictions are scarce. In this large cohort study we compare the <90-days dislocation rate between patients receiving posterior approach THA managed with minimal versus extensive restrictions.
Methods: Prospective cohort ( = 1049) of consecutive elective primary hip replacement surgery procedures (September 2014-July 2017) managed with minimal postoperative restrictions. Hospital charts were prospectively reviewed for patient demographics, risk factors and any hip dislocation. Control ( = 1102) consecutive primary elective THAs (January 2011-August 2014) managed with a traditional restrictive protocol. A posterior surgical approach was used in all procedures.
Results: Minimal restrictions group: 17 dislocations <90 days (1.6%); Restricted group: 28 (2.5%), chi-square = 0.1. Testing the hypothesis of inferiority by a minimum of 1% increase in ⩽90 days dislocation risk: = 0.14 (test for difference) and < 0.001 (non-inferiority test), allowing us to discard the null hypothesis (absolute increase in risk of ⩾1% with minimal restrictions). The proportion of surgeries performed with a femoral head size ⩾32 mm was higher in the minimal restrictions group.
Conclusions: Patients can be managed safely with minimal restrictions following posterior approach THA if combined with frequent use of larger femoral heads.
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http://dx.doi.org/10.1177/1120700018823504 | DOI Listing |
J Eval Clin Pract
September 2025
Health Technology Assessment Unit, Acute and Hospital-Based Care Portfolio, Ontario Health, Toronto, Ontario, Canada.
Rationale: Systematic reviews are essential for evidence-based healthcare decision-making. While it is relatively straightforward to quantitatively assess random errors in systematic reviews, as these are typically reported in primary studies, the assessment of biases often remains narrative. Primary studies seldom provide quantitative estimates of biases and their uncertainties, resulting in systematic reviews rarely including such measurements.
View Article and Find Full Text PDFBrain Spine
January 2025
Department of Neurosurgery, Oslo University Hospital, Oslo, Norway.
Purpose: Isolated spinal aneurysms (iSAs) are rare, with an uncertain natural history and no established treatment guidelines. Multiple iSAs are even more uncommon, complicating treatment decisions.
Methods: This study reports a case of a ruptured radiculo-pial artery aneurysm in a patient with multiple iSAs, treated with surgical excision, assisted by intraoperative neurophysiological monitoring (IONM).
Bayesian Anal
January 2025
Department of Statistics, University of Washington, Seattle, USA.
We introduce the BREASE framework for the Bayesian analysis of randomized controlled trials with binary treatment and outcome. Approaching the problem from a causal inference perspective, we propose parameterizing the likelihood in terms of the aseline isk, fficacy, and dverse ide ffects of the treatment, along with a flexible, yet intuitive and tractable jointly independent beta prior distribution on these parameters, which we show to be a generalization of the Dirichlet prior for the joint distribution of potential outcomes. Our approach has a number of desirable characteristics when compared to current mainstream alternatives: (i) it naturally induces prior dependence between expected outcomes in the treatment and control groups; (ii) as the baseline risk, efficacy and risk of adverse side effects are quantities commonly present in the clinicians' vocabulary, the hyperparameters of the prior are directly interpretable, thus facilitating the elicitation of prior knowledge and sensitivity analysis; and (iii) we provide analytical formulae for the marginal likelihood, Bayes factor, and other posterior quantities, as well as an exact posterior sampling algorithm and an accurate and fast data-augmented Gibbs sampler in cases where traditional MCMC fails.
View Article and Find Full Text PDFCureus
August 2025
Department of Oral and Maxillofacial Surgery, Centre Hospitalier Universitaire (CHU) de Lille, University of Lille, Lille, FRA.
Orthodontic decompensation prior to orthognathic surgery often requires complex mandibular tooth movements. These movements depend on stable posterior anchorage, which is not always reliably achieved with miniscrews or miniplates. This case report describes the case of an 18-year-old patient undergoing presurgical orthodontic treatment, in whom bilateral Abalakov anchorage was performed.
View Article and Find Full Text PDFStat Med
September 2025
Berry Consultants, Abingdon, UK.
Confidence distributions are a frequentist alternative to the Bayesian posterior distribution. These confidence distributions have received more attention in the recent past because of their simplicity. In rare diseases, oncology, or in pediatric drug development, single-arm trials, or platform trials consisting of a series of single-arm trials are increasingly being used, both to establish proof-of-concept and to provide pivotal evidence for a marketing application.
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