Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
The global spread of carbapenem-resistant Acinetobacter baumannii (A. baumannii) strains has restricted the therapeutic options available to treat infections due to this pathogen. Understanding the prevalence of such infections and the underlying genetic mechanisms of resistance may help in the implementation of adequate measures to control and prevent acquisition of nosocomial infections, especially in an intensive care unit setting. This study describes the molecular characteristics and risk factors associated with OXA-23-producing A. baumannii infections. A case-control study was undertaken from September/2013 to April/2015. Acquisition of OXA-23-producing A. baumannii was found to be associated with the use of nasogastric tubes, haemodialysis, and the use of cephalosporins. These isolates were only susceptible to amikacin, gentamicin, tigecycline, and colistin, and contained the ISAba1 insertion sequence upstream ofblaOXA-23 and blaOXA-51 genes. Twenty-six OXA-23-producing A. baumannii strains belonged to the ST79 (CC79) clonal group,and patients infected or colonised by these isolates had a higher mortality rate (34.6%). In conclusion, this study showed a dissemination of OXA-23-producing A. baumannii strains that was associated with several healthcare-related risk factors and high mortality rates among intensive care unit patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6310363 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209367 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Phylogenomic analysis of aquatic and clinical OXA-23-positive belonging to the international clone 5 (ST79) from Southeast Brazil.
One Health
December 2025
Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil.
Categorized as a critical priority pathogen by the World Health Organization (WHO), carbapenem-resistant (CRAB) is a leading cause of healthcare-associated infections (HAIs) worldwide. Although the environmental spread of healthcare-acquired strains through hospital wastewater and urban sewage has been suggested, evidence from genomic studies is still lacking. In this study, as part of the Grand Challenges Explorations: New Approaches to Characterize the Global Burden of Antimicrobial Resistance Program, we present genomic data supporting the expansion of international clone IC5/ST79 (Pasteur) to an anthropogenically impacted urban river in Brazil.
View Article and Find Full Text PDFEmergence of NDM-1- and OXA-23-Co-Producing ST1 Isolates from a Burn Unit in Spain.
Microorganisms
May 2025
Laboratorio de Referencia e Investigación en Resistencia a Antibióticos e Infecciones Relacionadas con la Asistencia Sanitaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28222 Madrid, Spain.
The global emergence of carbapenem-resistant (CRAB) represents a significant public health threat. In the summer of 2022, a polyclonal CRAB outbreak occurred in our hospital, marking the first detection of an NDM-1 plus OXA-23 co-producing strain in Spain. The aim of this study was to phenotypically and genotypically characterize the clonal spread of NDM-1 and OXA-23 co-producing isolates and to describe the infection control measures implemented to contain the outbreak.
View Article and Find Full Text PDFUnveiling transposon-mediated multidrug resistance in OXA-23-producing Acinetobacter baumannii ST79/ST233 subclone KL9-OCL10 in Brazil.
Gene
July 2025
Department of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Brazil. Electronic address:
The global dissemination of antimicrobial resistance (AMR) is a critical public health concern. The persistence of AMR in the environmental sector, exemplified by carbapenem-resistant Acinetobacter baumannii (CRAB), underscores the critical interconnectedness between human activity, environmental contamination, and the global spread of multidrug-resistant bacterial pathogens. In this study, A.
View Article and Find Full Text PDFDetection of OXA-23-producing Proteus mirabilis in Switzerland.
Eur J Clin Microbiol Infect Dis
March 2025
Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.
Proteus mirabilis is a Gram-negative bacterium found in the environment and also forms part of the commensal flora in the gastrointestinal tract of both humans and animals. P. mirabilis can cause a wide variety of infections, however it does not harbor any intrinsic β-lactamase genes and as such usually exhibits full susceptibility to β-lactams with the exception of imipenem, to which it is naturally resistant.
View Article and Find Full Text PDFEffect of colistin-tigecycline combination on colistin-resistant and carbapenem-resistant and .
Microbiol Spectr
February 2025
Department of Microbiology, Sungkyunkwan University School of Medicine, Suwon, South Korea.
Unlabelled: There is a critical need for treatment strategies to combat carbapenem-resistant Gram-negative pathogens. This study investigates the efficacy of combining low concentrations of colistin with tigecycline against colistin- and carbapenem-resistant and strains. We used two strains of KPC-2-producing and OXA-23-producing , both of which are highly colistin-resistant.
View Article and Find Full Text PDF