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Purpose: Cancer risks for Nagasaki survivors once appeared to be lower than for Hiroshima survivors. The possibility that this was due to overestimation of the doses for the Nagasaki survivors was tested by measuring biological doses of Nagasaki survivors and comparing them with DS02R1 individual doses as previously done for Hiroshima survivors.
Materials And Methods: The electron spin resonance (ESR) method and cytogenetic method were used to estimate radiation doses for 24 Nagasaki survivors, and the results were compared to calculated DS02R1 doses.
Results: Six factory workers and 10 other survivors showed ESR or cytogenetically estimated doses that were in reasonably good agreement with their DS02R1 doses, while one factory worker was found to have an ESR dose estimate of nearly one half of the DS02R1 dose to the eye lens (a proxy organ for teeth). A few outliers were also observed.
Conclusions: Although apparently lower cancer risks were observed in the past for Nagasaki survivors when compared to Hiroshima survivors, the present results do not indicate the existence of a trend that DS02R1 doses are overestimated when compared with biologically estimated tooth or cytogenetic doses. This observation is in line with the recent disappearance of the city difference in cancer risks.
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http://dx.doi.org/10.1080/09553002.2019.1552807 | DOI Listing |
Background: The involvement of primary care physicians (PCPs) is essential to meet the diverse needs of cancer survivors, yet their engagement remains insufficient. Consequently, identifying the factors associated with PCPs' practices in each component of cancer survivorship care is crucial. However, there is no study on the factors for individual care components.
View Article and Find Full Text PDFInt J Hematol
September 2025
Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, Japan.
Adult T-cell leukemia-lymphoma (ATL) is one of the most intractable peripheral T-cell neoplasms caused by human T-cell leukemia virus type I (HTLV-1) infection. Recently, the incidence of HTLV-1 infection and ATL has increased in non-endemic metropolitan areas in Japan. This retrospective study evaluated the clinical features and outcomes of patients with aggressive ATL aged 70 years or younger treated at a core hospital in Tokyo between 2004 and 2016.
View Article and Find Full Text PDFEur J Cancer
August 2025
Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan.
Background: Checkpoint inhibitor pneumonitis (CIP), especially graded as 3-5 or developed within 6-12 weeks, worsens the prognosis of patients with cancer. However, a risk assessment method for the disease has not been established. This was a prospective study that aimed to identify a blood biomarker to assess a risk of severe CIP.
View Article and Find Full Text PDFTransplant Cell Ther
July 2025
Department of Hematology, National Center for Global Health and Medicine, Shinjuku, Tokyo, Japan. Electronic address:
Although allogeneic hematopoietic stem cell transplantation (SCT) remains a potentially curative treatment option for several myeloid malignancies, despite the fact that the average age at disease onset for myeloid malignancies is approximately 70 years of age, its applicability in elderly patients is challenging. We retrospectively evaluated the outcomes of elderly SCT patients with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS), using a nationwide Japanese registry database. We analyzed the data of 3609 patients ranging from 65 to 79 years of age with AML or MDS who underwent initial SCT between 2003 and 2022, while focusing on those 70 to 74 (n = 645) and 75 to 79 years old (n = 65).
View Article and Find Full Text PDFFukushima J Med Sci
May 2025
Department of Public Health, Fukushima Medical University School of Medicine.
Purpose: Since the nuclear power plant accident in Fukushima, there has been anxiety about the effects of radiation exposure on future generations, specifically that the effects of radiation exposure may be inherited by descendants. We explored the relationship between health literacy and knowledge of the genetic effects of radiation exposure on this anxiety in both men and women.
Methods: In August 2016, a mail survey was conducted among 2,000 Fukushima residents aged 20-79 years.