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We piloted a health navigation strategy to promote timely linkage to care among men who have sex with men (MSM) and transgender women (TW) recently diagnosed with HIV in Guatemala City. We used a mixed-methods approach, integrating quantitative data collected during clinic visits and qualitative data from in-depth interviews, to characterize acceptability of navigation and time to linkage, defined as having the first clinical care visit. Out of 54 participants who enrolled in the pilot (n = 52 MSM; n = 2 TW), 50 (92.6%) accepted navigation and all were linked to care. Median time to linkage was 3 days (Interquartile Range 2-5 days). In qualitative interviews, participants expressed feeling scared and alone following their diagnosis and appreciated the support of a navigator, especially when they did not feel they could access their existing support networks. Future research and evaluation should continue to assess how to best use health navigation to support key populations recently diagnosed with HIV.
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http://dx.doi.org/10.1007/s10461-018-2328-6 | DOI Listing |
Nat Chem Biol
September 2025
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Many pharmaceutical targets partition into biomolecular condensates, whose microenvironments can significantly influence drug distribution. Nevertheless, it is unclear how drug design principles should adjust for these targets to optimize target engagement. To address this question, we systematically investigated how condensate microenvironments influence drug-targeting efficiency.
View Article and Find Full Text PDFJMIR Res Protoc
September 2025
Moores Cancer Center, University of California, San Diego, La Jolla, CA, United States.
Background: Cancer screening nonadherence persists among adults who are deaf, deafblind, and hard of hearing (DDBHH). These barriers span individual, clinician, and health care system levels, contributing to difficulties understanding cancer information, accessing screening services, and following treatment directives. Critical communication barriers include ineffective patient-physician communication, limited access to American Sign Language (ASL) cancer information, misconceptions about medical procedures, insurance navigation difficulties, and intersectional barriers for multiply marginalized individuals.
View Article and Find Full Text PDFJ Pediatr Nurs
September 2025
School of Nursing and Midwifery, Griffith University, Queensland, Australia. Electronic address:
Background And Purpose: Siblings of children with chronic health conditions face unique psychosocial challenges, yet their voices remain underrepresented in research. While existing studies primarily rely only on parental proxy reports of sibling well-being or focus on experiences of older siblings or are confined to specific conditions like cancer, there is limited understanding of siblings' experiences more broadly from their voice. This study investigated the experiences of siblings of children with chronic health conditions in Australia from both sibling and parental perspectives.
View Article and Find Full Text PDFPLoS One
September 2025
Wake Forest University School of Medicine, Department of Implementation Science, Winston-Salem, North Carolina, United States of America.
Background: Hepatitis C virus (HCV) and injection drug use among young women are dramatically rising in the rural United States. From 2004 to 2017, heroin use among non-pregnant women increased 22.4% biennially, mirroring increases in HCV cases, especially among younger populations.
View Article and Find Full Text PDFJ Nurses Prof Dev
September 2025
Mary Beth Russell, PhD, MA, RN, NPDA-BC®, NEA-BC, FNAP, CPHQ, CNE®, is Senior Vice President, The Center for Professional Development, Innovation, Research, The Institute for Nursing Excellence, RWJBarnabas Health, and Executive Dean, RWJBarnabas Health School of Nursing, West Orange, New Jersey.
The system nursing professional development (NPD) leader functions across multiple healthcare locations to standardize practice, implement enterprise-wide initiatives, and align NPD functions with strategic goals. This role connects professional development, operations, and leadership while navigating unique site needs. Through strategic implementation and outcome-driven decision-making, the system NPD leader impacts staff competency, engagement, and patient safety.
View Article and Find Full Text PDF