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Evaluation of intrathoracic pressure is the cornerstone of the understanding of heart-lung interactions, but is not easily feasible at the bedside. Esophageal pressure (P) has been shown to be a good surrogate for intrathoracic pressure and can be more easily measured using a small esophageal catheter, but is not routinely employed. It can provide crucial information for the study of heart-lung interactions in both controlled and spontaneous ventilation. This review presents the physiological basis, the technical aspects and the value in clinical practice of the measurement of P.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6186557 | PMC |
http://dx.doi.org/10.21037/atm.2018.05.04 | DOI Listing |
Cancer Pathog Ther
September 2025
State Key Laboratory of Oncology in South China, Collaborative Innovation Centre for Cancer Medicine, Guangdong Esophageal Cancer Institute, United Laboratory of Frontier Radiotherapy Technology of Sun Yat-sen University & Chinese Academy of Sciences Ion Medical Technology Co., Guangzhou, Guangdong
Volatile organic compounds (VOCs) are carbon-based chemicals characterized by high vapor pressure and low boiling points under standard temperature and pressure conditions. VOCs are categorized as exogenous or endogenous, depending on their source. Endogenous VOCs are metabolic byproducts eliminated via respiration.
View Article and Find Full Text PDFDiabetes Obes Metab
September 2025
Department of Minimally Invasive Surgery, Hernias and Abdominal Wall Surgery, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Clinical Research Center for Gastroesophageal Reflux Disease and Bariatric Metabolic Surgery, Research Institute of General and Minimally Invasive Surgery, Ur
Aims: This randomised controlled trial compared the efficacy of modified laparoscopic sleeve gastrectomy with fundoplication (LSGFD) versus standard laparoscopic sleeve gastrectomy (LSG) in achieving weight loss and alleviating gastroesophageal reflux disease (GERD) in patients with obesity.
Materials And Methods: Eighty patients with obesity (body mass index [BMI] ≥27.5 kg/m with comorbidities or ≥32.
Gastro Hep Adv
June 2025
Leeds Institute of Medical Research, University of Leeds, Leeds, UK.
Background And Aims: Gastroesophageal reflux (GER) is common and thought to contribute to disease progression in patients with respiratory disease. Delayed gastric emptying (DGE) can increase GER in patients with GER disease, but its effect in patients with respiratory disease, and how differing lung structure (eg, scarring, inflammation) and mechanics (eg, decreased thoracic pressure in restrictive disease, increased abdominal pressure in obstructive disease) influences this is unknown. Our aim was to understand these interrelationships and association with pulmonary function in patients with chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and non-IPF interstitial lung disease (non-IPF ILD).
View Article and Find Full Text PDFObjectives: Peroral endoscopic myotomy (POEM) is an established treatment for esophageal achalasia. Despite favorable outcomes, the risk of reflux aspiration during general anesthesia induction in POEM remains a concern. This study aimed to identify the risk factors for food residue in the esophagus before POEM and evaluate the necessity of esophagogastroduodenoscopy (EGD) and cleansing the day before POEM.
View Article and Find Full Text PDFSurg Endosc
September 2025
Department of Surgery and Experimental Surgery, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
Introduction: Esophagectomy was considered the first line for advanced sigmoid (aSg) achalasia (esophageal angulation < 90°), while laparoscopic Heller myotomy (LHM) has a lower percentage of success. The pull-down LHM (PD-LHM) technique has emerged as a promising and more effective rescue therapy to avoid esophagectomy for aSg achalasia. However, the long-term functional results of PD-LHM are inconclusive.
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