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We report a child with Lennox-Gastaut syndrome with an increase in seizure frequency and loss of psychomotor skills due to a disintegrated cervical VNS lead, not detected during standard device monitoring. The lead was completely removed and replaced by a new 303 lead on the same nerve segment. After reinitiating VNS, side effects forced us to switch it off, resulting in immediate seizure recurrence. EEG recording demonstrated a non-convulsive status epilepticus that was halted by reinitiating VNS therapy. Thereafter, he remained seizure free for eight months, and regained psychomotor development.
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http://dx.doi.org/10.1016/j.ebcr.2018.08.002 | DOI Listing |
Immune Netw
August 2025
Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul 03722, Korea.
Developmental and epileptic encephalopathies (DEEs), including Infantile Epileptic Spasms Syndrome (IESS) and Lennox-Gastaut Syndrome (LGS), are severe pediatric conditions characterized by profound developmental delays and treatment-resistant epilepsy. Although steroid therapies provide some clinical benefits, the underlying immunological mechanisms remain poorly understood. In this study, we performed comprehensive immune profiling using multi-parametric flow cytometry on PBMCs from IESS (n=25) and LGS (n=9) patients, comparing them with age-matched healthy controls (n=54).
View Article and Find Full Text PDFExpert Rev Med Devices
September 2025
Division of Child Neurology, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Stereotact Funct Neurosurg
September 2025
Deep brain stimulation (DBS) targeting the centromedian (CM) thalamic nucleus is an emerging treatment option for patients with Lennox-Gastaut syndrome. Ten LGS patients with CM-DBS underwent one-hour scalp EEG approximately one-month post-surgery. Following a 10-minute baseline EEG, stimulation commenced at 1V for 5 minutes, increasing in 1V increments up to 5V or until paresthesias occurred.
View Article and Find Full Text PDFYakugaku Zasshi
August 2025
Department of Neurosurgery, St. Marianna University School of Medicine.
Cannabidiol (CBD) is an abundant phytocannabinoid extracted from Cannabis sativa L., along with delta-9-tetrahydrocannabinol. Plant-derived, highly purified CBD oral solution (100 mg/mL) is approved as Epidiolex in the United States and as Epidyolex in Europe for the treatment of seizures associated with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex with country-specific labels.
View Article and Find Full Text PDFEpilepsy Behav
August 2025
Jane and John Justin Institute for Mind Health, Cook Children's Medical Center, Ft. Worth, TX, USA. Electronic address:
Objective: Provide the perspective of caregivers planning for adulthood in people with developmental and epileptic encephalopathies (DEEs).
Results: Family members (N = 134) of people with DEE (1-44 years old) responded to an anonymous, internet-based survey to assess the needs of DEE families. Respondents included parents/guardians (n = 121, 90.