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Background: Intraoperative transfusion manage- ment is difficult during laparoscopic surgery, because peumoperitoneum affects hemodynamics. We studied whether stroke volume variation (SVV) is useful as an indicator of transfusion management Methods : We studied 44 patients undergoing lapa- roscopic colectomy. Patients were randomly allocated to two groups, and the volume of transfusion was decided with the SVV as an indicator in one group (SVV group, n=22) or with conventional indicators, such as blood pressure, heart rate, volume of urine in the other group (control group, n=22) Results : In the SVV group, total transfusion volume and total blood loss during operation were significantly decreased, and the length of hospital stay was signifi- cantly shorter, compared with the control group.
Conclusions: We believe that the SVV is a useful indicator of intraoperative transfusi6h management during laparoscopic colectomy.
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Cureus
August 2025
Neuroanesthesia, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, IND.
Introduction: Maintaining hemodynamic stability during the perioperative period of major neurosurgical procedures is of paramount importance. A major challenge for anesthesiologists during hemodynamic fluctuations is identifying the underlying cause to guide appropriate therapy. Limited literature is available on the utility of transesophageal echocardiography (TEE) during hemodynamic fluctuations in major neurosurgery.
View Article and Find Full Text PDFBiomed Eng Lett
September 2025
Department of Anesthesiology and Pain Medicine, Brain Korea 21 Project, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpagu, 05505 Seoul, Republic of Korea.
Heart sounds provide essential information about cardiac function; however, their clinical meaning and potential for minimally invasive hemodynamic monitoring in real world clinical settings remain underexplored. This study assessed relationships between heart sound indices and hemodynamic parameters during liver transplant surgery. Data from 80 liver transplant recipients were analyzed across five procedural phases (approximately 1,680k cardiac beats).
View Article and Find Full Text PDFJ Biomed Mater Res B Appl Biomater
September 2025
Contipro a.s., Czech Republic.
Drug delivery to the central nervous system (CNS) is primarily hindered by the blood-brain barrier (BBB). To address this, mucoadhesive formulations have been designed to prolong residence time at the application site. In this study, we comprehensively characterized the physicochemical and mucoadhesive properties of hyaluronic acid tyramine (HATA) photocrosslinked hydrogels using rheological methods, nanoindentation, contact angle goniometry, and advanced confocal microscopy.
View Article and Find Full Text PDFDrug Des Devel Ther
August 2025
Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou, People's Republic of China.
Objective: This study aimed to investigate the impact of two-stage goal-directed crystalloid versus colloid fluid therapy on postoperative quality of recovery in patients undergoing laparoscopic hepatectomy.
Patients And Methods: A total of 116 patients scheduled for elective laparoscopic hepatectomy were randomly assigned to two groups: the goal-directed fluid therapy (GDFT) crystalloid group and the GDFT colloid group. Both groups were monitored for stroke volume variation (SVV) using the FloTrac/Vigileo system, and GDFT was guided based on SVV values.
Cureus
July 2025
Department of Physical Therapy, Juntendo University, Tokyo, JPN.
Thalamic astasia (TA) is a condition characterized by difficulty maintaining an upright posture due to a unilateral lesion in the thalamus. Motor paralysis, sensory disturbances, and ataxia are typically absent or mild. While vestibular dysfunction has been implicated in the onset of TA, a comprehensive evaluation strategy that considers vestibular function has yet to be established.
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