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http://dx.doi.org/10.1136/gutjnl-2018-316988 | DOI Listing |
Biology (Basel)
August 2025
Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand.
Anemia remains a widespread public health concern, and the search for interventions demonstrating potent anti-anemic activity is critical for reducing its impact among high-risk populations. Conventional iron therapies are associated with several complications and potential adverse effects. This study explored a polyherbal approach to develop a safer and more effective alternative treatment for anemia.
View Article and Find Full Text PDFMedicine (Baltimore)
August 2025
Department of Hematology, Ankara University School of Medicine, Ankara, Turkey.
Iron deficiency anemia (IDA) is a common general health problem in daily clinical practice. A large amount of iron in the body is used for hemoglobin (Hb) synthesis and iron is critical for many biological functions such as cell proliferation, energy production, DNA synthesis and respiration. In recent years, with a better understanding of iron metabolism; it has led to the need to review treatment regimens in the treatment of IDA.
View Article and Find Full Text PDFNutrients
August 2025
QIMR Berghofer Medical Research Institute, Brisbane, QLD 4006, Australia.
Background: Iron is an essential nutrient for many bacterial pathogens and normal cellular function and homeostasis of their hosts. Studies suggest that iron deficiency or overload may contribute to the pathogenesis of several chronic conditions and modify host-microbial interactions. In this study, we assessed the impact of varying dietary iron intakes on the microbiota of the intestinal tract and lungs of wild-type mice.
View Article and Find Full Text PDFLife (Basel)
July 2025
Department of Pediatrics, Saitama Medical University Hospital, Moroyama, Saitama 350-0495, Japan.
An explorative study was conducted to evaluate the efficacy and safety of 5-aminolevulinic acid hydrochloride combined with sodium ferrous citrate (SPP-004) in 10 pediatric patients with Leigh syndrome (LS) aged 3-24 months in 10 institutions between December 2014 and July 2019. The patients were randomized and allocated to the SPP-004 or placebo group for a 12-week double-blind period, followed by a 12-week open-label period with SPP-004 and then a long-term study of up to 180 weeks. The efficacy and safety were evaluated using the Newcastle Pediatric Mitochondrial Disease Scale (NPMDS) and adverse events (AEs), respectively.
View Article and Find Full Text PDFClin Med Insights Case Rep
August 2025
Squad Medicine and Research (SMR), Amadalavalasa, Andhra Pradesh, India.
Methemoglobinemia is a rare but potentially life-threatening condition characterized by the oxidation of hemoglobin iron from ferrous (Fe²⁺) to ferric (Fe³⁺) state, impairing its oxygen-carrying capacity. Acquired forms can be triggered by exposure to oxidizing agents, such as nitrobenzene. We present the case of a 32-year-old female who developed symptomatic methemoglobinemia following oral ingestion of a commercial stimulant product containing nitrobenzene.
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