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http://dx.doi.org/10.1016/j.jcmg.2018.07.025 | DOI Listing |
Cureus
August 2025
Emergency Medicine, Stockport NHS Foundation Trust, Stockport, GBR.
Kounis syndrome, also known as allergic myocardial infarction, is a rare but potentially life-threatening condition in which acute coronary events are triggered by an allergic reaction. The pathophysiology involves mast cell degranulation and the release of inflammatory mediators such as histamine, leukotrienes, and platelet-activating factor, leading to coronary vasospasm, myocardial ischemia, or infarction. We present the case of a female patient in her 80s with no prior history of coronary artery disease who developed anaphylaxis shortly after intravenous administration of co-amoxiclav in the emergency department.
View Article and Find Full Text PDFInt J Cardiol
September 2025
Department of Demography and Geodemography, Faculty of Science, Charles University, Prague, Czech Republic.
Background: Alcohol septal ablation (ASA) is an established therapy for symptomatic hypertrophic obstructive cardiomyopathy (HOCM) in patients unresponsive to medical treatment. However, comprehensive assessment of ASA outcomes remains challenging. This study aimed to evaluate the impact of institutional experience and patient characteristics on achieving complete clinical and haemodynamic response (CCHR), a novel composite outcome integrating long-term symptomatic, haemodynamic, safety, and major clinical endpoints, including survival and resuscitation.
View Article and Find Full Text PDFAdv Physiol Educ
September 2025
Swansea University Medical School, Swansea University, Swansea, UK.
The chick embryo ventricular cardiomyocyte model provides students easy access to experiments involving fundamental features of cardiac cell physiology and pharmacology. Using standard physiology teaching laboratories and basic cell culture equipment, spontaneously beating colonies of electrically-connected cardiomyocytes can be obtained by the students themselves. Students learn, aseptic techniques and cell culture alongside experiments illustrating, at the simplest level of experimentation, how beating rate can be altered physiologically or pharmacologically.
View Article and Find Full Text PDFCureus
August 2025
Department of Surgery, University of Minnesota, Minneapolis, USA.
Postoperative atrial fibrillation (POAF) is a common complication following anatomic lung resection, contributing to increased morbidity and mortality, prolonged hospital stays, and higher healthcare costs. Despite its frequency, there remains limited consensus on optimal pharmacologic management in this population, particularly in the context of balancing efficacy with the unique risks associated with thoracic surgery. This report aims to draw attention to the clinical significance of POAF in thoracic surgery, particularly following pulmonary resections, by presenting a representative case and contextualizing it through a focused review of current literature and consensus guidelines.
View Article and Find Full Text PDFFront Cardiovasc Med
August 2025
Department of Cardiology, Qingpu Branch of Zhongshan Hospital Affiliated to Fudan University, Shanghai, China.
Background: Acute myocardial infarction in the elderly often leads to significant left ventricular structural remodeling, which adversely affects prognosis. This study aims to evaluate the effects of intensive rosuvastatin therapy on markers of ventricular remodeling and cardiac function following percutaneous coronary intervention (PCI) in elderly patients with ST-segment elevation myocardial infarction (STEMI).
Methods: This study enrolled 100 patients aged ≥60 years with STEMI who underwent emergency PCI.