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Serotonin 5-HT and 5-HT receptors differentially modulate the acquisition and expression of voluntary alcohol drinking in male mice.
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Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilhéus, Brazil.
Introduction: Studies suggest that serotonin (5-HT) plays an important role in alcohol use disorder (AUD). While several receptor subtypes modulate the role of 5-HT in AUD, evidence suggests that 5-HT and 5-HT receptors may be directly involved in alcohol drinking due to their interaction with the mesolimbic dopaminergic system. The aim of the present study was to investigate the effects of 5-HT and 5-HT antagonists, alone or in combination, on the acquisition and expression (i.
View Article and Find Full Text PDFExploring the Effects of Psilocybin on Depression and the Mediating Role of the 5-HT2A Receptor: A Systematic Review.
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September 2025
Department of Developmental and Personality Psychology, Laboratory of Experimental Psychology, Neuroscience, and Behavior (LPNeC), Universidade Federal of Rio Grande do Sul (UFRGS), Brazil.
Background: Major depressive disorder (MDD) is a significant public health concern, and current treatments often have limitations in effectiveness and adherence. Psilocybin, a psychedelic compound found in certain mushrooms, is being explored as a potential treatment for depression. It primarily acts through the serotonin 5-HT2A receptor but interacts with 5-HT1A and 5-HT2C receptors.
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bioRxiv
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Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90025-7239, USA.
Unlabelled: Serotonin (5-HT) is a hormonal messenger that confers state-level changes upon the nervous system in both humans and flies. In , lobula columnar (LC) cells are feature-detecting neurons that project from the optic lobe to the central brain, where each population forms an anatomically-distinct glomerulus with heterogeneous synaptic partners. Here, we investigated serotonin's effect on two LC populations with different 5-HT receptor expression profiles.
View Article and Find Full Text PDFSerotonin selectively modulates visual responses of object motion detectors in .
J Neurophysiol
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Department of Integrative Biology and Physiology, University of California, Los Angeles, Los Angeles, CA 90025-7239, USA.
Serotonin (5-HT) is a hormonal messenger that confers state-level changes upon the nervous system in both humans and flies. In , lobula columnar (LC) cells are feature-detecting neurons that project from the optic lobe to the central brain, where each population forms an anatomically distinct glomerulus with heterogeneous synaptic partners. Here, we investigated serotonin's effect on two LC populations with different 5-HT receptor expression profiles.
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Int J Mol Sci
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Department of Physiological Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland.
Sleep paralysis (SP), an REM parasomnia, can be characterized as one of the symptoms of narcolepsy. The SP phenomenon involves regaining meta-consciousness by the dreamer during REM, when the physiological atonia of skeletal muscles is accompanied by visual and auditory hallucinations that are perceived as vivid and distressing nightmares. Sensory impressions include personification of an unknown presence, strong chest pressure sensation, and intense fear resulting from subjective interaction with the unfolding nightmare.
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