Article Synopsis
- Up to 72% of patients with cannabis allergy (CA) experiencing likely-anaphylaxis are sensitized to Can s 3, the key protein linked to CA, highlighting its significance in diagnosis.
- The study evaluated five cannabis diagnostic tests, with specific IgE tests and skin prick tests showing the best predictive values for confirming CA.
- Patients sensitized to Can s 3 reported more severe reactions to other allergens and higher incidences of systemic reactions to plant-derived foods, suggesting a broader allergy risk beyond cannabis itself.
Video Abstracts
Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: Cannabis allergy (CA) has mainly been attributed to Can s 3, the nonspecific lipid transfer protein (nsLTP) of Cannabis sativa. Nevertheless, standardized diagnostic tests are lacking and research on CA is scarce.
Objective: To explore the performance of 5 cannabis diagnostic tests and the phenotypic profile of CA.
Methods: A total of 120 patients with CA were included and stratified according to the nature of their cannabis-related symptoms; 62 healthy and 189 atopic controls were included. Specific IgE (sIgE) hemp, sIgE and basophil activation test (BAT) with a recombinant Can s 3 protein from Cannabis sativa (rCan s 3), BAT with a crude cannabis extract, and a skin prick test (SPT) with an nCan s 3-rich cannabis extract were performed. Clinical information was based on patient history and a standardized questionnaire.
Results: First, up to 72% of CA reporting likely-anaphylaxis (CA-A) are Can s 3 sensitized. Actually, the Can s 3-based diagnostic tests show the best combination of positive and negative predictive values, 80% and 60%, respectively. sIgE hemp displays 82% sensitivity but only 32% specificity. Secondly, Can s 3+CA reported significantly more cofactor-mediated reactions and displayed significantly more sensitizations to other nsLTPs than Can s 3-CA. Finally, the highest prevalence of systemic reactions to plant-derived foods was seen in CA-A, namely 72%.
Conclusions: The most effective and practical tests to confirm CA are the SPT with an nCan s 3-rich extract and the sIgE rCan s 3. Can s 3 sensitization entails a risk of systemic reactions to plant-derived foods and cofactor-mediated reactions. However, as Can s 3 sensitization is not absolute, other cannabis allergens probably play a role.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jaip.2018.09.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Diagnosis and management of thyroid nodule.
Curr Opin Endocrinol Diabetes Obes
October 2025
Department of Surgery, American Mission Hospital, Manama, Bahrain.
Purpose Of Review: To review the current medical evidence in the diagnosis and management of thyroid nodules.
Recent Findings: The widespread use of imaging modalities in recent years has led to frequent discovery of incidental thyroid nodules. These nodules are mostly benign (over 90%), hence precise insight in evaluating nodules of concern and following up other nodules is important to avoid unnecessary surgeries and its complications.
99mTc-Labeled Cefixime for Targeted Imaging of Infections: Preclinical Evaluation and Potential in Postpartum Women.
Infect Disord Drug Targets
September 2025
Department of Chemistry, NFC Institute of Technology, Multan, Pakistan.
Introduction: Targeted infection imaging is crucial for accurate diagnosis in postpartum women. This project uses 99mTc-labeled cefixime to develop a radiopharmaceutical for detecting, distinguishing, and treating infections and abscesses in women.
Method: Technetium (TcO4-) chelated with cefixime, reduced by stannous chloride, confirmed via thin-layer chromatography.
[Rotator cuff tear].
Ugeskr Laeger
September 2025
fdeling for Led- og Knoglekirurgi, Københavns Universitetshospital - Herlev og Gentofte Hospital.
The clinical presentation of rotator cuff ruptures varies greatly and ranges from no symptoms to severe shoulder impairment. Clinical shoulder tests are an effective screening tool to identify patients who require early specialist assessment or further radiological investigation, but they are not sufficient to rule out smaller ruptures. Small ruptures can often be managed non-surgically, while larger traumatic ruptures may necessitate early surgical intervention.
View Article and Find Full Text PDFDiagnosing prenatal alcohol exposure and fetal alcohol syndrome in military-connected children: Insights from US military data claims, 2016-2023.
Alcohol Clin Exp Res (Hoboken)
September 2025
Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Background: Fetal alcohol spectrum disorder (FASD) is a lifelong neurodevelopmental condition resulting from prenatal alcohol exposure (PAE) during gestation. Conservative estimates of FASD prevalence in United States children are 1%-5%. Early identification could facilitate early intervention, yet fewer than 1% of children with FASD receive a diagnosis.
View Article and Find Full Text PDFAge-related insulin resistance changes in children and adolescents and its impact on the accuracy of diagnosis of metabolic syndrome.
Ann Pediatr Endocrinol Metab
August 2025
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Purpose: Although insulin resistance (IR) varies with age and puberty in children and adolescents, most previous attempts to determine cutoff values for IR indices overlook factor. This study assesses age-related differences in IR index values and evaluates how diagnostic performance varies by age when using a uniform cutoff for diagnosing metabolic syndrome (MetS) without considering age.
Methods: We analyzed age-related differences in IR indices (the homeostatic model assessment of insulin resistance [HOMA-IR], triglyceride-glucose [TyG] index, and triglyceride/high-density lipoprotein cholesterol [TG/HDL-C] ratio) among 1,641 participants in the 2019-2021 Korea National Health and Nutrition Examination Survey.