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http://dx.doi.org/10.7326/L18-0300 | DOI Listing |
Diabetes Metab Syndr Obes
August 2025
Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia.
Purpose: Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors represent major advancements in the management of type 2 diabetes. However, many patients remain suboptimally managed with these therapies. This underutilization highlights the need for practical implementation strategies in real-world settings.
View Article and Find Full Text PDFCardiovasc Diabetol
August 2025
Cardiology Department, Meir Medical Center, 59 Tchernichovsky St, 44281, Kfar Saba, Israel.
Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2-I) and glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to reduce cardiovascular risk and mortality in patients with type 2 diabetes mellitus (T2D), yet remain underutilized in clinical practice. This study aimed to evaluate real-world treatment patterns and associated mortality outcomes among patients with T2D and established atherosclerotic cardiovascular disease (ASCVD).
Methods: The CARdiovascular and DIABetes (CARDIAB) cohort included 138,397 patients with T2D and ASCVD.
Biomedicines
August 2025
Department of Cardiology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Cardiovascular-Kidney-Metabolic (CKM) syndrome symbolizes a single pathophysiologic entity including obesity, type 2 diabetes, chronic kidney disease, and cardiovascular disease. These conditions altogether accelerate adverse outcomes when they coexist. Recent evidence has shown that the function of glucagon-like peptide-1 receptor agonists (GLP-1RA) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) alleviate stress on multiple organs.
View Article and Find Full Text PDFJ Clin Gastroenterol
June 2025
Icahn School of Medicine at Mount Sinai, Division of Liver Diseases, New York, NY.
Goals: Our aim was to perform a national survey of provider attitudes, practices, and knowledge regarding weight loss and MASLD medications in patients with MASLD.
Background: While weight loss is a cornerstone in the management of metabolic dysfunction-associated steatotic liver disease (MASLD), FDA-approved medications for weight loss remain underutilized.
Results: We conducted a survey before resmetirom approval of hepatology and gastroenterology providers practicing in 44 states.
Expert Opin Pharmacother
June 2025
Department of Internal Medicine, University of Texas-Southwestern, Dallas, TX, USA.
Introduction: Cardiometabolic diseases, particularly type 2 diabetes (T2D) and cardiovascular disease (CVD), represent leading global health challenges with rising incidence and prevalence. Despite strong evidence supporting the benefits of sodium-glucose cotransporter inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) in managing CVD risk in T2D, these therapies remain underutilized.
Areas Covered: This review discusses the present state of SGLT2i and GLP-1 RA usage, emphasizing barriers to their adoption, including clinical inertia, high costs, and misconceptions about injectable therapies.