98%
921
2 minutes
20
Bat populations harbour a multitude of viruses; some of these are pathogenic or potentially pathogenic in other animals or humans. Therefore, it is important to monitor the populations and characterize these viruses. In this study, the presence of coronaviruses (CoVs) in different species of Danish bats was investigated using active surveillance at different geographical locations in Denmark. Faecal samples were screened for the presence of CoVs using pan-CoV real-time RT-PCR assays. The amplicons, obtained from five different species of bats, were sequenced. Phylogenetic analysis revealed a species-specific clustering with the samples from , showing a close resemblance to coronavirus sequences obtained from the same species of bat in Germany and the United Kingdom. Our results show, for the first time, that multiple, distinct alphacoronaviruses are present in the Danish bat populations.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163574 | PMC |
http://dx.doi.org/10.3390/v10090486 | DOI Listing |
PLoS Pathog
September 2025
Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Coronaviruses, including SARS-CoV-2, rely on host factors for their replication and pathogenesis, while hosts deploy defense mechanisms to counteract viral infections. Although numerous host proviral factors have been identified, the landscape of host restriction factors and their underlying mechanisms remain less explored. Here, we conducted genome-wide CRISPR knockout screens using three distinct coronaviruses-SARS-CoV-2, HCoV-OC43 (a common cold human virus from the genus Betacoronavirus) and porcine epidemic diarrhea virus (Alphacoronavirus) to identify conserved host restriction factors.
View Article and Find Full Text PDFmBio
August 2025
Departments of Microbiology & Immunology and Public & Ecosystem Health, Cornell University, Ithaca, New York, USA.
Alphacoronaviruses are widespread but understudied in comparison to betacoronaviruses. Within the alphacoronaviruses is the species , which comprises distinct viruses of cats, dogs, and pigs, along with a separate species that infects mustelids-as well as other related viruses of pigs and circulating human viruses. High-pathogenicity feline coronavirus (FCoV) is infamous as the cause of feline infectious peritonitis (FIP), existing as two distinct genotypes (types 1 and 2) and transmitted as a low-pathogenicity virus.
View Article and Find Full Text PDFJ Mol Evol
August 2025
Laboratório de Imunologia e Biologia Molecular, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Bats are considered a unique group of mammals and are recognized as natural hosts for a variety of emerging viral agents of One Health importance. In Brazil, nine bat families are described, of which the family Phyllostomidae contains the highest number of cataloged species. Within them, the Pallas's long-tongued bat (Glossophaga soricina) is one of the most widely distributed species in South America.
View Article and Find Full Text PDFEcohealth
August 2025
Centre Interdisciplinaire de Recherches Médicales de Franceville (CIRMF), BP769, Franceville, Gabon.
Zoonotic diseases are increasingly affecting global health, making it crucial to understand viral dynamics in wildlife reservoirs like bats. Bats are well-established coronavirus reservoirs, and their proximity to human habitats in France raises concerns about zoonotic transmission. This study investigates the prevalence, diversity, and phylogenetic relationships of coronaviruses in bats from the Camargue and Eastern Provence, two ecologically distinct regions.
View Article and Find Full Text PDFmBio
August 2025
EcoHealth Alliance, New York, New York, USA.
Bats are the reservoir hosts of emerging coronaviruses (CoVs) affecting human and livestock health. We assessed the diversity, evolution, and geographic distribution of two alphacoronaviruses (subgenus ) with considerable potential for emergence: swine acute diarrhea syndrome coronavirus (SADS-CoV), which has caused large outbreaks in pigs in China and can infect primary human airway epithelial cells ; and the related (HKU2-CoV). Phylogenetic analyses of 523 rhinacovirus sequences from bats in China and Southeast Asia suggest these viruses should be reclassified into at least two distinct CoV species representing two well-supported monophyletic clades.
View Article and Find Full Text PDF