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http://dx.doi.org/10.1038/s41467-018-05310-5 | DOI Listing |
Nat Commun
September 2023
Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Nat Commun
August 2018
Division of Psychiatry, University of Edinburgh, EH10 5HF, Edinburgh, UK.
Global incidence rates for inflammatory bowel disease (IBD) have gradually risen over the past 20 years. Genome-wide association studies (GWAS) have identified over 160 genetic loci associated with IBD; however, inherited factors only account for a partial contribution to the disease risk. We have recently shown that urban airborne particulate matter (PM) ingested via contaminated food can alter gut microbiome and immune function under normal and inflammatory conditions.
View Article and Find Full Text PDFGut Microbes
February 2013
Teagasc Food Research Centre, Cork, Ireland.
A recent comparative genomic hybridization study in our laboratory revealed considerable plasticity within the bacteriocin locus of gastrointestinal strains of Lactobacillus salivarius. Most notably, these analyses led to the identification of two novel unmodified bacteriocins, salivaricin L and salivaricin T, produced by the neonatal isolate L. salivarius DPC6488 with immunity, regulatory and export systems analogous to those of abp118, a two-component bacteriocin produced by the well characterized reference strain L.
View Article and Find Full Text PDFPlant Signal Behav
May 2010
Plant Research International, Bioscience, Wageningen, The Netherlands.
Receptor-like proteins (RLPs) are cell surface receptors, which are composed of several distinct domains including a signal peptide, an extracellular leucine-rich repeat (LRR) region, a transmembrane domain and a short cytoplasmic tail. RLPs are implicated in plant growth and development as well as in disease resistance. Our previous genome-wide functional analysis of 57 Arabidopsis RLP genes (AtRLPs) revealed that mutant phenotypes were only observed for a few genes including the two reported genes CLAVATA2 (CLV2) and TOO MANY MOUTHS, despite the wide range of growth and developmental stages and treatments that were tested.
View Article and Find Full Text PDF