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Objective: Schizophrenia patients have deficits in premorbid adjustment (PMA) and social cognition (SC); both deficits are associated with symptom severity, neuro-cognitive deficits, and prognosis. This study aimed to determine symptom severity and two domains of SC deficit by assessing specific areas of PMA in schizophrenia patients.
Methods: This cross-sectional study included 60 male and 60 female patients with paranoid schizophrenia aged 20 to 35 years from two psychiatric inpatient departments of Chhattisgarh state of India. They were assessed using the Scale for Assessment of Positive Symptoms, Scale for Assessment of Negative Symptoms, Premorbid Adjustment Scale, Recognition of Facial Expression Task, and Picture Arrangement Test.
Results: Deficits in premorbid sociability and in scholastic performance were the best predictors of severity of positive symptoms, social knowledge, and negative emotion recognition deficit in schizophrenia patients.
Conclusion: Given the important role of SC and PMA, assessing premorbid functioning can help in deciding early and appropriate intervention for schizophrenia.
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J Clin Neurosci
September 2025
Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital Hsin-Chu Branch, Hsin-chu, Taiwan; Department of Physical Medicine and Rehabilitation, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taiwan. Electronic address: b96401093@n
Objectives: The aim of this study is to investigate the association between masticatory muscle thickness and dysphagia in intracerebral hemorrhage (ICH) patients.
Materials & Methods: This retrospective cohort study included patients with spontaneous ICH confirmed by brain computed tomography (CT) between June 2019 and June 2024 in a university-affiliated hospital. Temporal muscle thickness (TMT) and masseter muscle thickness (MMT) were measured on the initial brain CT.
Top Stroke Rehabil
August 2025
Department of Neurosurgery, Itami Kousei Neurosurgical Hospital, Itami, Japan.
Background: The frailty index (FI) has been reported as a useful measure for assessing premorbid conditions in stroke patients; however, its significance in evaluating post-stroke status remains unclear.
Aims: This study aims to clarify the role of FI as a tool for assessing post-stroke conditions.
Methods: This retrospective cohort study included stroke patients admitted to an acute-care hospital.
Nutrients
August 2025
Division of Geriatric Medicine, Department of Medicine, National University Hospital, Singapore 119228, Singapore.
Background: Malnutrition contributes to frailty dementia, intensifying adverse health outcomes including mortality risk.
Objectives: We aim to investigate the impact of malnutrition risk in those with frailty and functional decline on short-term mortality among older adults with dementia and/or cognitive impairment.
Methods: We conducted a retrospective cohort study involving 2677 hospitalized patients aged ≥65 years with a diagnosis of dementia or cognitive impairment discharged between March 2022 and December 2023.
Brain Sci
August 2025
Department of Neurology, Justus-Liebig-University, 35392 Giessen, Germany.
Posterior cranial fossa (PCF) infarctions are associated with elevated mortality rates; however, evidence regarding the prognostic value of comorbidity indices in this context remains scarce. This study investigates the association between the age-adjusted Charlson Comorbidity Index (aCCI) and clinical outcomes in patients with PCF infarctions, aiming to evaluate the aCCI as a prognostic indicator. The aCCI is a validated scoring system that quantifies a patient's burden of chronic diseases, adjusting for age, to estimate overall comorbidity risk.
View Article and Find Full Text PDFEur J Radiol
August 2025
Department of Neurosurgery, Kobe City Medical Center General Hospital, Hyogo, Japan.
Background And Purpose: The time-varying relationship between ischemic core volume and neurological outcomes remains uncertain. This study aimed to evaluate how this relationship changes over time in patients undergoing mechanical thrombectomy (MT) and create visual probability heat maps to help clinical decision-making.
Methods: We reviewed data from 168 patients who underwent successful MT (mTICI 2b-3) between March 2021 and December 2023.