Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Phenolic compounds constitute one of the most promising and ubiquitous groups with many biological activities. Synergistic interactions between natural phenolic compounds and antibiotics could offer a desired alternative approach to the therapies against multidrug-resistant bacteria. The objective of the presented study was to assess the antibacterial potential of caffeic acid (CA) alone and in antibiotic-phytochemical combination against reference and clinical strains isolated from infected wounds. The caffeic acid tested in the presented study showed diverse effects on strains with the minimum inhibitory concentration (MIC) varied from 256 g/mL to 1024 g/mL. The supplementation of Mueller-Hinton agar (MHA) with 1/4 MIC of CA resulted in augmented antibacterial effect of erythromycin, clindamycin, and cefoxitin and to the lesser extent of vancomycin. The observed antimicrobial action of CA seemed to be rather strain than antibiotic dependent. Our data support the notion that CA alone exerts antibacterial activity against clinical strains and has capacity to potentiate antimicrobial effect in combination with antibiotics. The synergy between CA and antibiotics demonstrates its potential as a novel antibacterial tool which could improve the treatment of intractable infections caused by multidrug-resistant strains.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6076962 | PMC |
| http://dx.doi.org/10.1155/2018/7413504 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Caffeic acid phenethyl ester disrupts germ layer specification in Xenopus embryos.
Reprod Toxicol
September 2025
Department of Biochemistry and Molecular Biology, Brain Korea 21 Project, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, South Korea. Electronic address:
Xenopus embryo serves as an ideal model for teratogenesis assays to observe the effects of any compounds on the cellular processes crucial for early development and adult tissue homeostasis. In our screening of a chemical library with frog embryo, caffeic acid phenethyl ester (CAPE) was found to upregulate the FGF/MAPK pathway, disrupting germ layer formation in early development. Exposure to CAPE interfered with the formation of anterior-posterior body axis and of ectodermal derivatives such as eyes, dorsal fin and pigment cells.
View Article and Find Full Text PDFCOF-derived multicore-shell FeCo nanoalloys@N-doped carbon for sensitive electrochemical detection of caffeic acid.
Food Chem
August 2025
Department of Chemistry & IMO-IMOMEC, Hasselt University, 3590 Diepenbeek, Belgium.
Caffeic acid is a key indicator of wine quality, but its sensitive and accurate detection remains challenging due to the lack of high-performance sensing materials. Metal/N-doped porous carbon (M/NPC) electrocatalysts with abundant catalytic sites are promising to address this issue. Herein, a FeCo nanoalloy encapsulated in NPC (FeCo@NPC) was designed and synthesized via a "covalent organic framework (COF) adsorption-pyrolysis" strategy.
View Article and Find Full Text PDFIdentification of the first plant caffeoyl-quinate esterases in .
Front Plant Sci
August 2025
Joint Laboratory CHIC41H University of Lille-Florimond-Desprez, Université de Picardie Jules Verne, Université de Liège, Univ. Lille, Junia, UMRT 1158 BioEcoAgro - Specialized Metabolites of Plant Origin, Villeneuve d'Ascq, France.
Chlorogenic acid (5-CQA) is a caffeic acid ester widely accumulated in higher plants. It plays roles in defense against biotic and abiotic stresses. As its biosynthetic pathway shares common enzymes and intermediates with that of lignin, 5-CQA has long been hypothesized to be involved in lignin formation.
View Article and Find Full Text PDFComprehensive Metabolomic Profiling and Biological Activity Analysis of Extracts Using LC-ESI-QTOF-MS.
Food Sci Nutr
September 2025
Physiology and Biochemistry Laboratory, Department of Biology, Science Faculty Selcuk University Konya Turkey.
The current investigation was designed to explore the chemical composition, antioxidant capacity, enzyme inhibitory activity, and cytotoxic potential of four different extracts (Ethyl Acetate, Ethanol, Ethanol/Water (70%) and Water) derived from the aerial parts of . In vitro, assessments were performed utilizing diverse antioxidant assays, along with evaluations of neuroprotective enzyme inhibition targeting acetylcholine and butyl choline enzymes, as well as antidiabetic activities against α-amylase and α-glucosidase and a potential candidate for a tyrosinase inhibitor. LC-ESI-QTOF-MS identification provided a total of 70 compounds in the extracted samples of , including kaempferol 3-(deoxyhexosyl-hexoside)-7-hexoside, rutin, quercetin dideoxyhexoside, caffeic acid hexoside, quinoline alkaloids, morphine derivatives, and scoulerine.
View Article and Find Full Text PDFPluripotent Cinnamic Acid and Valproic Acid Hybrid Molecules Designed as Strong Anti-inflammatory and Anti-hyperlipidemic Compounds.
Med Chem
September 2025
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece.
Introduction: Inflammation and oxidative stress are considered main pathophysiological factors for neuronal and cardiovascular diseases, also leading to the impairment of main cellular metabolic pathways. Promotion of hyperlipidemia is also the result of inflammatory and oxidative (ROS production) processes. Additionally, compounds of medicinal interest like valproic and caffeic acids and amino acids like proline and tyrosine have shown antiinflammatory and cellular protective potency.
View Article and Find Full Text PDF