Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Infection with enterotoxigenic (ETEC) is an important cause of diarrhea-related illness and death among children under 5 years of age in low- and middle-income countries (LMIC). Recent studies have found that it is the ETEC subtypes that produce the heat-stable enterotoxin (ST), irrespective of whether they also secrete the heat-labile enterotoxin (LT), which contribute most importantly to the disease burden in children from LMIC. Therefore, adding an ST toxoid would importantly complement ongoing ETEC vaccine development efforts. The ST's potent toxicity, its structural similarity to the endogenous peptides guanylin and uroguanylin, and its poor immunogenicity have all complicated the advancement of ST-based vaccine development. Recent remarkable progress, however, including the unprecedented screening for optimal ST mutants, mapping of cross-reacting ST epitopes and improved ST-carrier coupling strategies (bioconjugation and genetic fusion), enables the rational design of safe, immunogenic, and well-defined ST-based vaccine candidates.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6663125 | PMC |
| http://dx.doi.org/10.1080/21645515.2018.1496768 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Women's Unique Health Needs and the Sustainable Development Goals: A Meeting Report from the 79th United Nations General Assembly Science Summit.
J Womens Health (Larchmt)
September 2025
Centre of Excellence Women and Child Health, Aga Khan University, Nairobi, Kenya.
Biological sex, hormones, and gender uniquely affect health and disease, often resulting in disparities for women across the lifespan and from different racial and ethnic groups, geographical locations, and socioeconomic backgrounds. Without intentional investment and infrastructure to support good health and wellbeing for women, half of the world's population remains vulnerable to preventable morbidity and mortality. The Society for Women's Health Research and ECHAlliance-The Global Health Connector convened a women's health program as part of the 10th Annual Science Summit during the United Nations 79th General Assembly.
View Article and Find Full Text PDFRecent Advances in Plant-Based Vaccines: From Molecular Farming Innovations to Global Health Applications.
Biotechnol J
September 2025
Joint International Research Laboratory of Agriculture and Agri-Product Safety of the Ministry of Education, Yangzhou University, Yangzhou, China.
Vaccines are pivotal in mitigating infectious diseases by reducing infection rates, severity, and mortality. Plant-derived vaccines-engineered to express antigens in plants, offer distinctive advantages, including cost-efficient production, enhanced biosafety profiles, superior thermal stability, and simplified logistics. Recent advances in plant biotechnology have enabled the large-scale production of plant-based vaccines, positioning them as a viable and transformative alternative to conventional vaccine platforms.
View Article and Find Full Text PDFAAV-mediated delivery of a broadly neutralizing anti-flavivirus antibody protects against dengue and Zika viruses in a mouse model.
Mol Ther
September 2025
Institute of Biomedical Sciences, Academia Sinica, Taipei 115201, Taiwan,; Institute of Microbiology and Immunology, National Defense Medical Center, Taipei 114201, Taiwan, ; Biomedical Translation Research Center, Academia Sinica, Taipei 115201, Taiwan,. Electronic address:
Flaviviruses contain many important human pathogens such as dengue virus (DENV) and Zika virus (ZIKV), for which effective and safe vaccines are still lacking, mainly because pre-existing cross-reactive non-neutralizing antibodies may exacerbate subsequent infections with related flaviviruses. To overcome this challenge, we explore Vectored ImmunoProphylaxis (VIP), which involves the passive transfer of protective antibody genes via viral vectors for in vivo expression. We utilized a recombinant adeno-associated virus (rAAV) to express a broad anti-flavivirus neutralizing human monoclonal antibody, bnAb 752-2C8, and tested its protection against four serotypes of DENV and ZIKV.
View Article and Find Full Text PDFHost Immune Response to Respiratory Syncytial Virus Infection in Children.
Influenza Other Respir Viruses
September 2025
Department of Respiratory, Children's Hospital of Nanjing Medical University, Nanjing, China.
Respiratory syncytial virus (RSV) is one of the leading causes of severe respiratory diseases in children, especially in infants. The immune responses induced by RSV infection are a fairly complex process that can contribute significantly to disease severity. Despite decades of research on RSV, many immune mechanisms remain to be explored.
View Article and Find Full Text PDFMyths, mandates, and decision-making: A qualitative exploration of COVID-19 vaccine hesitancy among pregnant and postpartum women in Pakistan.
Vaccine
September 2025
Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Background: Among pregnant and postpartum women, decision-making for receiving the COVID-19 vaccine is influenced by vaccine safety concerns, misconceptions, shifting vaccine policies, and exclusion in the initial vaccine rollout. This caused confusion and vaccine hesitancy among many groups including pregnant and postpartum women.
Objective: The objective of this study was to understand the multilevel factors that influence vaccine decision-making among pregnant and postpartum women in Pakistan, which is crucial for improving vaccine demand among the vulnerable group-pregnant and postpartum women.