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Background: Acute annular retinopathy (AAOR) is a rare entity showing grayish spots with annular lesions. We report the clinical characteristics of a patient with AAOR derived by using multimodal imaging including spectral-domain optical coherence tomography (OCT), fundus autofluorescence (FAF), and an adaptive optics fundus camera. Case: A 56-year-old man who had fever one month and a half before presenting. He noticed bilateral visual loss after lowering of fever. Clinical findings: Grayish white rings of different sizes were seen in the posterior fundus. Margin of the lesion showed hyperautofluorescence. OCT demonstrated an indistinct ellipsoid zone, disruption of external limiting membrane, and bulging of the retinal pigment epithelium in the annular lesions. We found hyperreflective foci in the inner retina and an indistinct interdigitation zone on the OCT images and indistinct cone mosaic patterns on the AO images at an ophthalmoscopically normal fovea in the left eye. Conclusion: Multimodal imaging showed the damage in the photoreceptors and the retinal pigment epithelium at the annular lesions. OCT and AO imaging can demonstrate abnormal findings in ophthalmoscopically normal areas in eyes with AAOR.
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JACC Case Rep
August 2025
Cardiovascular Center Surgery Department, Toranomon Hospital, Tokyo, Japan.
Background: Caseous calcification of the mitral annulus (CCMA), a rare variant of mitral annular calcification, is occasionally associated with calcified amorphous tumors (CATs). These distinctive lesions are poorly documented, particularly regarding their potential for mobility and embolism.
Case Summary: A 73-year-old woman presented with acute left-sided hemiparesis and dysarthria.
Skin Appendage Disord
May 2025
Dermatology Department, Dermatologic Institute of Jalisco "Dr. Jose Barba Rubio", Zapopan, Mexico.
Introduction: Frontal fibrosing alopecia is a type of alopecia diagnosed predominantly clinically. A glabellar skin biopsy provides important findings in cases of diagnostic uncertainty, such as red dots, representing the presence of a perifollicular lymphocytic inflammatory infiltrate affecting the vellus hairs.
Case Presentation: A 74-year-old patient with 10 months of progressive frontal hair loss was observed upon examination to show alopecia with a "fringe sign," consistent with a type III pattern of frontal fibrosing alopecia.
Ann Med Surg (Lond)
July 2025
Department of Pathology, Nepal Medical College and Teaching Hospital, Kathmandu University, Jorpati, Kathmandu, Nepal.
Introduction And Importance: Porokeratosis is a rare keratinization disorder marked by atrophic patches with a distinct hyperkeratotic border known as a cornoid lamella. Genital porokeratosis (GP), especially involving the penis, is extremely uncommon, with only a handful of cases reported worldwide. This case report describes the first instance of penile porokeratosis from Nepal, highlighting its rarity and clinical presentation.
View Article and Find Full Text PDFJ Interv Card Electrophysiol
August 2025
Division of Cardiology, Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA, USA.
Background: Mitral isthmus block (MIB) complicating radiofrequency ablation (RFA) of orthodromic reciprocating tachycardia (ORT) using left - sided accessory pathways (APs) is poorly understood.
Methods: Two cases and a systematic review of the literature of patients (pts) who developed MIB complicating left - sided ORT RFA is presented.
Results: Among 27 pts (34 ± 12 years old, 54% female, 68% concealed AP), 15 (56%) had ≥ 1 failed RFA procedure.
BMC Med Imaging
August 2025
Department of Ultrasound, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing, China.
Background: This study aims to develop a machine learning (ML)-based predictive model for evaluating the efficacy of percutaneous pulmonary balloon angioplasty (BPA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) by integrating clinical and echocardiographic parameters. By comparing the predictive performance of different algorithms, we aimed to establish a robust tool to identify patients most likely to benefit from BPA.
Methods: We retrospectively included 135 inoperable CTEPH patients who underwent BPA between January 2017 and September 2024.